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Open AccessFeature PaperArticle

Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier

1
Nanoscale Science Program, Department of Chemistry, University of North Carolina Charlotte, Charlotte, NC 28223-0001, USA
2
Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, Frederick, MD 21702, USA
3
Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L7 3NY, UK
*
Authors to whom correspondence should be addressed.
Academic Editors: Ashok Kakkar and Anne-Marie Caminade
Molecules 2021, 26(3), 652; https://doi.org/10.3390/molecules26030652
Received: 30 December 2020 / Revised: 20 January 2021 / Accepted: 21 January 2021 / Published: 27 January 2021
Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these studies have used a single lipid-based carrier to allow for NANPs’ intracellular delivery, it is now apparent that the platform for delivery, which has historically been a hurdle for therapeutic nucleic acids, is an additional means to tailoring NANP immunorecognition. Here, the use of dendrimers for the delivery of NANPs is compared to the lipid-based platform and the differences in resulting cytokine induction are presented. View Full-Text
Keywords: nucleic acid nanoparticles; NANPs; cytokines; vaccines; immunotherapies; immunology nucleic acid nanoparticles; NANPs; cytokines; vaccines; immunotherapies; immunology
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MDPI and ACS Style

Avila, Y.I.; Chandler, M.; Cedrone, E.; Newton, H.S.; Richardson, M.; Xu, J.; Clogston, J.D.; Liptrott, N.J.; Afonin, K.A.; Dobrovolskaia, M.A. Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier. Molecules 2021, 26, 652. https://doi.org/10.3390/molecules26030652

AMA Style

Avila YI, Chandler M, Cedrone E, Newton HS, Richardson M, Xu J, Clogston JD, Liptrott NJ, Afonin KA, Dobrovolskaia MA. Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier. Molecules. 2021; 26(3):652. https://doi.org/10.3390/molecules26030652

Chicago/Turabian Style

Avila, Yelixza I.; Chandler, Morgan; Cedrone, Edward; Newton, Hannah S.; Richardson, Melina; Xu, Jie; Clogston, Jeffrey D.; Liptrott, Neill J.; Afonin, Kirill A.; Dobrovolskaia, Marina A. 2021. "Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier" Molecules 26, no. 3: 652. https://doi.org/10.3390/molecules26030652

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