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Article

The Impact of Redox, Hydrolysis and Dehydration Chemistry on the Structural and Magnetic Properties of Magnetoferritin Prepared in Variable Thermal Conditions

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Institute of Hydrology SAS, Dúbravská Cesta 9, 84104 Bratislava, Slovakia
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Institute of Materials Research Slovak Academy of Sciences, Watsonova 47, 04001 Košice, Slovakia
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Institute of Experimental Physic SAS, Watsonova 47, 04001 Košice, Slovakia
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Institut Laue-Langevin, 71 Avenue des Martyrs, 38042 Grenoble, France
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Helmholtz-Zentrum Hereon, Max-Planck-Street 1, 21502 Geesthacht, Germany
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Joint Institute for Nuclear Research, Joliot-Curie Str. 6, 141980 Dubna, Russia
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BCMaterials, Basque Centre for Materials, Applications and Nanostructures, 48940 Leioa, Spain
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IKERBASQUE, Basque Foundation for Science, 48009 Bilbao, Spain
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Institute for Energy Security and Environmental Safety, Centre for Energy Research, Konkoly Thege Mi-klos ut 29-33, 1121 Budapest, Hungary
*
Authors to whom correspondence should be addressed.
Academic Editor: Giuseppe Cirillo
Molecules 2021, 26(22), 6960; https://doi.org/10.3390/molecules26226960
Received: 17 September 2021 / Revised: 15 November 2021 / Accepted: 16 November 2021 / Published: 18 November 2021
Ferritin, a spherically shaped protein complex, is responsible for iron storage in bacteria, plants, animals, and humans. Various ferritin iron core compositions in organisms are associated with specific living requirements, health state, and different biochemical roles of ferritin isomers. Magnetoferritin, a synthetic ferritin derivative, serves as an artificial model system of unusual iron phase structures found in humans. We present the results of a complex structural study of magnetoferritins prepared by controlled in vitro synthesis. Using various complementary methods, it was observed that manipulation of the synthesis technology can improve the physicochemical parameters of the system, which is useful in applications. Thus, a higher synthesis temperature leads to an increase in magnetization due to the formation of the magnetite phase. An increase in the iron loading factor has a more pronounced impact on the protein shell structure in comparison with the pH of the aqueous medium. On the other hand, a higher loading factor at physiological temperature enhances the formation of an amorphous phase instead of magnetite crystallization. It was confirmed that the iron-overloading effect alone (observed during pathological events) cannot contribute to the formation of magnetite. View Full-Text
Keywords: magnetoferritin; magnetite; loading factor; protein stability; aqueous medium magnetoferritin; magnetite; loading factor; protein stability; aqueous medium
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MDPI and ACS Style

Balejčíková, L.; Saksl, K.; Kováč, J.; Martel, A.; Garamus, V.M.; Avdeev, M.V.; Petrenko, V.I.; Almásy, L.; Kopčanský, P. The Impact of Redox, Hydrolysis and Dehydration Chemistry on the Structural and Magnetic Properties of Magnetoferritin Prepared in Variable Thermal Conditions. Molecules 2021, 26, 6960. https://doi.org/10.3390/molecules26226960

AMA Style

Balejčíková L, Saksl K, Kováč J, Martel A, Garamus VM, Avdeev MV, Petrenko VI, Almásy L, Kopčanský P. The Impact of Redox, Hydrolysis and Dehydration Chemistry on the Structural and Magnetic Properties of Magnetoferritin Prepared in Variable Thermal Conditions. Molecules. 2021; 26(22):6960. https://doi.org/10.3390/molecules26226960

Chicago/Turabian Style

Balejčíková, Lucia, Karel Saksl, Jozef Kováč, Anne Martel, Vasil M. Garamus, Mikhail V. Avdeev, Viktor I. Petrenko, László Almásy, and Peter Kopčanský. 2021. "The Impact of Redox, Hydrolysis and Dehydration Chemistry on the Structural and Magnetic Properties of Magnetoferritin Prepared in Variable Thermal Conditions" Molecules 26, no. 22: 6960. https://doi.org/10.3390/molecules26226960

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