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Article

Chromane Derivatives from Underground Parts of Iris tenuifolia and Their In Vitro Antimicrobial, Cytotoxicity and Antiproliferative Evaluation

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Department of Chemistry, School of Biomedicine, Mongolian National University of Medical Sciences, S. Zorig Street 3, Ulaanbaatar 14210, Mongolia
2
Department of Pharmaceutical Chemistry, School of Pharmacy, Mongolian National University of Medical Sciences, S. Zorig Street 3, Ulaanbaatar 14210, Mongolia
3
Max Planck Institute for Chemical Ecology, Hans-Knoell-Strasse 8, D-07745 Jena, Germany
4
Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Adolf-Reichwein-Strasse 23, D-07745 Jena, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Biljana Božin and Neda Mimica-Dukić
Molecules 2021, 26(21), 6705; https://doi.org/10.3390/molecules26216705
Received: 14 October 2021 / Revised: 31 October 2021 / Accepted: 2 November 2021 / Published: 5 November 2021
(This article belongs to the Special Issue Bioactive Compounds from Plants with Pharmaceutical Interest)
Phytochemical investigation of the ethanol extract of underground parts of Iris tenuifolia Pall. afforded five new compounds; an unusual macrolide termed moniristenulide (1), 5-methoxy-6,7-methylenedioxy-4-O-2′-cycloflavan (2), 5,7,2′,3′-tetrahydroxyflavanone (3), 5-hydroxy-6,7-dimethoxyisoflavone-2′-O-β-d-glucopyranoside (9), 5,2′,3′-dihydroxy-6,7-dimethoxyisoflavone (10), along with seven known compounds (48, 1112). The structures of all purified compounds were established by analysis of 1D and 2D NMR spectroscopy and HR-ESI-MS. The antimicrobial activity of the compounds 13, 5, 9, and 10 was investigated using the agar diffusion method against fungi, Gram-positive and Gram-negative bacteria. In consequence, new compound 3 was found to possess the highest antibacterial activity against Enterococcus faecalis VRE and Mycobacterium vaccae. Cell proliferation and cytotoxicity tests were also applied on all isolated compounds and plant crude extract in vitro with the result of potent inhibitory effect against leukemia cells. In particular, the newly discovered isoflavone 10 was active against both of the leukemia cells K-562 and THP-1 while 46 of the flavanone type compounds were active against only THP-1. View Full-Text
Keywords: Iris tenuifolia; Iridaceae; chromane; macrolide; flavonoids; antimicrobial; antiproliferative effect; cytotoxicity Iris tenuifolia; Iridaceae; chromane; macrolide; flavonoids; antimicrobial; antiproliferative effect; cytotoxicity
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MDPI and ACS Style

Otgon, O.; Nadmid, S.; Paetz, C.; Dahse, H.-M.; Voigt, K.; Bartram, S.; Boland, W.; Dagvadorj, E. Chromane Derivatives from Underground Parts of Iris tenuifolia and Their In Vitro Antimicrobial, Cytotoxicity and Antiproliferative Evaluation. Molecules 2021, 26, 6705. https://doi.org/10.3390/molecules26216705

AMA Style

Otgon O, Nadmid S, Paetz C, Dahse H-M, Voigt K, Bartram S, Boland W, Dagvadorj E. Chromane Derivatives from Underground Parts of Iris tenuifolia and Their In Vitro Antimicrobial, Cytotoxicity and Antiproliferative Evaluation. Molecules. 2021; 26(21):6705. https://doi.org/10.3390/molecules26216705

Chicago/Turabian Style

Otgon, Oldokh, Suvd Nadmid, Christian Paetz, Hans-Martin Dahse, Kerstin Voigt, Stefan Bartram, Wilhelm Boland, and Enkhmaa Dagvadorj. 2021. "Chromane Derivatives from Underground Parts of Iris tenuifolia and Their In Vitro Antimicrobial, Cytotoxicity and Antiproliferative Evaluation" Molecules 26, no. 21: 6705. https://doi.org/10.3390/molecules26216705

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