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Article

Hepatoprotective Constituents of Total Dibenzocyclooctadiene Lignans from Schisandra chinensis Based on the Spectrum-Effect Relationship

1
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China
2
The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences/Guizhou Provincial Engineering Research Center for Natural Drugs, Guiyang 550014, China
3
Shanxi Province Key Laboratory of Environmental Pollution Control and Reservoir Protection Technology of Oilfields, Xi’an Shiyou University, Xi’an 710065, China
*
Author to whom correspondence should be addressed.
Academic Editor: Anna Petruczynik
Molecules 2021, 26(21), 6554; https://doi.org/10.3390/molecules26216554
Received: 26 September 2021 / Revised: 25 October 2021 / Accepted: 27 October 2021 / Published: 29 October 2021
(This article belongs to the Special Issue Natural Products: Isolation, Identification and Biological Activity)
To scientifically clarify the hepatoprotective constituents of Fructus Schizandrae chinensis, eleven batches samples of total dibenzocyclooctadiene lignans (TDL) from Schisandra chinensis were prepared by using the optimum extraction technique. Characteristic high-performance liquid chromatography (HPLC) chromatograms were obtained through HPLC analysis technology, and the hepatoprotective effects of the eleven batches of TDL were evaluated by MTT assay. Based on the chemical and biological activity results, the spectrum-effect relationship between the characteristic HPLC fingerprints and the hepatoprotective effect of TDL was established using Minitab 16.0 data analysis software. On the basis of the spectrum-effect relationship, thirteen compounds (113) were obtained from the TDL by chemical natural product chemical separation and purification technology, and their structures were identified on the basis of the spectral data and the literature. Based on these compounds, thirteen common peaks among the thirty-three chromatographic peaks in the above HPLC fingerprints were identified. Our findings showed that some components, including, schisandrin B (2), schisandrin A (3), and schisandrol B (7) had significant roles in promoting hepatoprotective activity. Preliminary verification of the spectrum-effect relationship of TDL from S. chinensis was carried out, and the results confirmed that the activity of a composite of these three key components in optimal ratios was better than that of any individual compound, which potentially confirmed the reliability of the spectrum-effect relationship and the synergistic effects of traditional Chinese medicine. View Full-Text
Keywords: Schisandra chinensis; total dibenzocyclooctadiene lignans (TDL); high-performance liquid chromatography (HPLC) fingerprint; hepatoprotective effects; spectrum-effect relationship; isolation and purification Schisandra chinensis; total dibenzocyclooctadiene lignans (TDL); high-performance liquid chromatography (HPLC) fingerprint; hepatoprotective effects; spectrum-effect relationship; isolation and purification
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MDPI and ACS Style

Deng, L.-L.; Xie, X.-D.; Li, J.; Wang, D.-P.; Hao, X.-J.; Chen, G.; Mu, S.-Z. Hepatoprotective Constituents of Total Dibenzocyclooctadiene Lignans from Schisandra chinensis Based on the Spectrum-Effect Relationship. Molecules 2021, 26, 6554. https://doi.org/10.3390/molecules26216554

AMA Style

Deng L-L, Xie X-D, Li J, Wang D-P, Hao X-J, Chen G, Mu S-Z. Hepatoprotective Constituents of Total Dibenzocyclooctadiene Lignans from Schisandra chinensis Based on the Spectrum-Effect Relationship. Molecules. 2021; 26(21):6554. https://doi.org/10.3390/molecules26216554

Chicago/Turabian Style

Deng, Lu-Lu, Xu-Dong Xie, Jiang Li, Dao-Ping Wang, Xiao-Jiang Hao, Gang Chen, and Shu-Zhen Mu. 2021. "Hepatoprotective Constituents of Total Dibenzocyclooctadiene Lignans from Schisandra chinensis Based on the Spectrum-Effect Relationship" Molecules 26, no. 21: 6554. https://doi.org/10.3390/molecules26216554

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