Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate
Abstract
:1. Introduction
2. Results and Discussion
2.1. Material Characterization
2.2. Release and Dissolution of CXB
2.3. Permeability of CXB across Caco-2 Cells
3. Materials and Methods
3.1. Materials
3.2. Synthesis of MMC
3.3. Drug Loading
3.4. Gas Sorption
3.5. TGA
3.6. XRD
3.7. DSC
3.8. Drug Release Measurement
3.9. Permeation Measurement
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Sample Availability
References
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tmax (min) | cmax (mg L−1) | AUC0–300 (mg min L−1) | |
---|---|---|---|
Pure CXB | 180 | 1.2 ± 0.1 | 306.2 |
MMC-CXB | 20 | 3.6 ± 0.1 | 735.6 |
N-CXB | 10 | 5.4 ± 0.1 | 737.8 |
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Gómez de la Torre, J.; Bergström, C.; Zardán Gómez de la Torre, T. Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate. Molecules 2021, 26, 6353. https://doi.org/10.3390/molecules26216353
Gómez de la Torre J, Bergström C, Zardán Gómez de la Torre T. Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate. Molecules. 2021; 26(21):6353. https://doi.org/10.3390/molecules26216353
Chicago/Turabian StyleGómez de la Torre, Johan, Christel Bergström, and Teresa Zardán Gómez de la Torre. 2021. "Increasing the Transport of Celecoxib over a Simulated Intestine Cell Membrane Model Using Mesoporous Magnesium Carbonate" Molecules 26, no. 21: 6353. https://doi.org/10.3390/molecules26216353