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Article

A Universal Cassette-Based System for the Dissolution of Solid Targets

1
Legnaro National Laboratories, National Institute for Nuclear Physics, 35020 Legnaro, Italy
2
Department of Industrial Engineering, University of Padova, 35131 Padova, Italy
3
Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy
4
Cyclotron & Radiopharmacy Department, Sacro Cuore Hospital, 37024 Negrar, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Anne Roivainen
Molecules 2021, 26(20), 6255; https://doi.org/10.3390/molecules26206255
Received: 17 September 2021 / Revised: 13 October 2021 / Accepted: 14 October 2021 / Published: 16 October 2021
(This article belongs to the Special Issue Metal-Based Radiopharmaceuticals in Inorganic Chemistry)
Cyclotron-based radionuclides production by using solid targets has become important in the last years due to the growing demand of radiometals, e.g., 68Ga, 89Zr, 43/47Sc, and 52/54Mn. This shifted the focus on solid target management, where the first fundamental step of the radiochemical processing is the target dissolution. Currently, this step is generally performed with commercial or home-made modules separated from the following purification/radiolabelling modules. The aim of this work is the realization of a flexible solid target dissolution system to be easily installed on commercial cassette-based synthesis modules. This would offer a complete target processing and radiopharmaceutical synthesis performable in a single module continuously. The presented solid target dissolution system concept relies on an open-bottomed vial positioned upon a target coin. In particular, the idea is to use the movement mechanism of a syringe pump to position the vial up and down on the target, and to exploit the heater/cooler reactor of the module as a target holder. All the steps can be remotely controlled and are incorporated in the cassette manifold together with the purification and radiolabelling steps. The performance of the device was tested by processing three different irradiated targets under different dissolution conditions. View Full-Text
Keywords: dissolution system; radiopharmaceutical; solid targets; automation; radiometals production; cyclotron production; radiochemistry; manganese-52; zirconium-89; technetium-99m dissolution system; radiopharmaceutical; solid targets; automation; radiometals production; cyclotron production; radiochemistry; manganese-52; zirconium-89; technetium-99m
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MDPI and ACS Style

Sciacca, G.; Martini, P.; Cisternino, S.; Mou, L.; Amico, J.; Esposito, J.; Gorgoni, G.; Cazzola, E. A Universal Cassette-Based System for the Dissolution of Solid Targets. Molecules 2021, 26, 6255. https://doi.org/10.3390/molecules26206255

AMA Style

Sciacca G, Martini P, Cisternino S, Mou L, Amico J, Esposito J, Gorgoni G, Cazzola E. A Universal Cassette-Based System for the Dissolution of Solid Targets. Molecules. 2021; 26(20):6255. https://doi.org/10.3390/molecules26206255

Chicago/Turabian Style

Sciacca, Gabriele, Petra Martini, Sara Cisternino, Liliana Mou, Jonathan Amico, Juan Esposito, Giancarlo Gorgoni, and Emiliano Cazzola. 2021. "A Universal Cassette-Based System for the Dissolution of Solid Targets" Molecules 26, no. 20: 6255. https://doi.org/10.3390/molecules26206255

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