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Communication

Peptide Blocking CTLA-4 and B7-1 Interaction

1
Russian-American Anti-Cancer Center, Altai State University, 61 Lenin St., 656049 Barnaul, Russia
2
Kizhner Research Center, National Research Tomsk Polytechnic University, 30 Lenin St., 634050 Tomsk, Russia
3
Center for Innovations in Medicine, Biodesign Institute, Arizona State University, 1001 S. McAllister Ave., Tempe, AZ 85281, USA
*
Author to whom correspondence should be addressed.
Molecules 2021, 26(2), 253; https://doi.org/10.3390/molecules26020253
Received: 18 December 2020 / Revised: 30 December 2020 / Accepted: 2 January 2021 / Published: 6 January 2021
(This article belongs to the Section Molecular Structure)
Discovery of the B7 family immune checkpoints such as CTLA-4 (CD152), PD-1 (CD279), as well as their ligands B7-1 (CD80), B7-2 (CD86), B7-H1 (PD-L1, CD274), and B7-DC (PD-L2, CD273), has opened new possibilities for cancer immunotherapy using monoclonal antibodies (mAb). The blockade of inhibitory receptors (CTLA-4 and PD-1) with specific mAb results in the activation of cancer patients’ T lymphocytes and tumor rejection. However, the use of mAb in clinics has several limitations including side effects and cost of treatment. The development of new low-molecular compounds that block immune checkpoints’ functional activity can help to overcome some of these limitations. In this paper, we describe a synthetic peptide (p344) containing 14 amino acids that specifically interact with CTLA-4 protein. A 3D computer model suggests that this peptide binds to the 99MYPPPY104 loop of CTLA-4 protein and potentially blocks the contact of CTLA-4 receptor with B7-1 ligand. Experimental data confirm the peptide-specific interaction with CTLA-4 and its ability to partially block CTLA-4/B7-1 binding. The identified synthetic peptide can be used for the development of novel immune checkpoint inhibitors that can block CTLA-4 functional activity for cancer immunotherapy. View Full-Text
Keywords: peptides; immune checkpoints; peptide microarray; cancer; immunotherapy peptides; immune checkpoints; peptide microarray; cancer; immunotherapy
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MDPI and ACS Style

Podlesnykh, S.V.; Abramova, K.E.; Gordeeva, A.; Khlebnikov, A.I.; Chapoval, A.I. Peptide Blocking CTLA-4 and B7-1 Interaction. Molecules 2021, 26, 253. https://doi.org/10.3390/molecules26020253

AMA Style

Podlesnykh SV, Abramova KE, Gordeeva A, Khlebnikov AI, Chapoval AI. Peptide Blocking CTLA-4 and B7-1 Interaction. Molecules. 2021; 26(2):253. https://doi.org/10.3390/molecules26020253

Chicago/Turabian Style

Podlesnykh, Stepan V., Kristina E. Abramova, Anastasia Gordeeva, Andrei I. Khlebnikov, and Andrei I. Chapoval 2021. "Peptide Blocking CTLA-4 and B7-1 Interaction" Molecules 26, no. 2: 253. https://doi.org/10.3390/molecules26020253

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