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Article

Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity

1
Medical Faculty, Institute for Drug Research, Hebrew University, Jerusalem 91120, Israel
2
Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK
3
180 Life Sciences, Menlo Park, CA 94025, USA
4
Lautenberg Center of Immunology and Cancer Research, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Mauro Maccarrone
Molecules 2021, 26(18), 5601; https://doi.org/10.3390/molecules26185601
Received: 30 July 2021 / Revised: 9 September 2021 / Accepted: 10 September 2021 / Published: 15 September 2021
Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other therapeutic benefits. Here we report the synthesis of three new CBG derivatives (HUM-223, HUM-233 and HUM-234) and show them to possess anti-inflammatory and analgesic properties. In addition, unlike CBG, HUM-234 also prevents obesity in mice fed a high-fat diet (HFD). The metabolic state of the treated mice on HFD is significantly better than that of vehicle-treated mice, and their liver slices show significantly less steatosis than untreated HFD or CBG-treated ones from HFD mice. We believe that HUM-223, HUM-233 and HUM-234 have the potential for development as novel drug candidates for the treatment of inflammatory conditions, and in the case of HUM-234, potentially for obesity where there is a huge unmet need. View Full-Text
Keywords: cannabinoid; cannabigerol; anti-inflammatory; obesity cannabinoid; cannabigerol; anti-inflammatory; obesity
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MDPI and ACS Style

Kogan, N.M.; Lavi, Y.; Topping, L.M.; Williams, R.O.; McCann, F.E.; Yekhtin, Z.; Feldmann, M.; Gallily, R.; Mechoulam, R. Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity. Molecules 2021, 26, 5601. https://doi.org/10.3390/molecules26185601

AMA Style

Kogan NM, Lavi Y, Topping LM, Williams RO, McCann FE, Yekhtin Z, Feldmann M, Gallily R, Mechoulam R. Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity. Molecules. 2021; 26(18):5601. https://doi.org/10.3390/molecules26185601

Chicago/Turabian Style

Kogan, Natalya M., Yarden Lavi, Louise M. Topping, Richard. O. Williams, Fiona E. McCann, Zhanna Yekhtin, Marc Feldmann, Ruth Gallily, and Raphael Mechoulam. 2021. "Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity" Molecules 26, no. 18: 5601. https://doi.org/10.3390/molecules26185601

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