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Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources

School of Chemical Engineering and Mineral Industries, University of Ngaoundere, 454 Ngaoundere, Cameroon
Department of Chemistry, Mugla Sitki Kocman University, Mugla 48000, Turkey
Department of Medical Services and Techniques, Koycegiz Vocational School of Health Services, Mugla Sitki Kocman University, Mugla 48800, Turkey
Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan
Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, Dunarea de Jos University, 47 Domneasca Str., 800008 Galati, Romania
Authors to whom correspondence should be addressed.
Academic Editors: Fengqing Yang, Jianbo Wan and Liya Ge
Molecules 2021, 26(18), 5582;
Received: 23 August 2021 / Revised: 8 September 2021 / Accepted: 10 September 2021 / Published: 14 September 2021
(This article belongs to the Special Issue Discovery of Enzyme Inhibitors from Natural Products)
Alzheimer’s disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world. This progressive brain deterioration affects the central nervous system and has negative impacts on a patient’s daily activities such as memory impairment. The most important challenge concerning AD is the development of new drugs for long-term treatment or prevention, with lesser side effects and greater efficiency as cholinesterases inhibitors and the ability to remove amyloid-beta(Aβ) deposits and other related AD neuropathologies. Natural sources provide promising alternatives to synthetic cholinesterase inhibitors and many have been reported for alkaloids while neglecting other classes with potential cholinesterase inhibition. This review summarizes information about the therapeutic potential of small natural molecules from medicinal herbs, belonging to terpenoids, coumarins, and phenolic compounds, and others, which have gained special attention due to their specific modes of action and their advantages of low toxicity and high efficiency in the treatment of AD. Some show superior drug-like features in comparison to synthetic cholinesterase inhibitors. We expect that the listed phytoconstituents in this review will serve as promising tools and chemical scaffolds for the discovery of new potent therapeutic leads for the amelioration and treatment of Alzheimer’s disease. View Full-Text
Keywords: Alzheimer’s disease; cholinesterase inhibitors; terpenoids; phenolic compounds; coumarins Alzheimer’s disease; cholinesterase inhibitors; terpenoids; phenolic compounds; coumarins
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MDPI and ACS Style

Tamfu, A.N.; Kucukaydin, S.; Yeskaliyeva, B.; Ozturk, M.; Dinica, R.M. Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources. Molecules 2021, 26, 5582.

AMA Style

Tamfu AN, Kucukaydin S, Yeskaliyeva B, Ozturk M, Dinica RM. Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources. Molecules. 2021; 26(18):5582.

Chicago/Turabian Style

Tamfu, Alfred N., Selcuk Kucukaydin, Balakyz Yeskaliyeva, Mehmet Ozturk, and Rodica M. Dinica 2021. "Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources" Molecules 26, no. 18: 5582.

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