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Review

Targeting Inflammation by Anthocyanins as the Novel Therapeutic Potential for Chronic Diseases: An Update

Department of Social Medicine and Public Health, Medical University of Warsaw, 02-776 Warsaw, Poland
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Author to whom correspondence should be addressed.
Academic Editors: Giuseppe Caruso, Nicolò Musso and Claudia Giuseppina Fresta
Molecules 2021, 26(14), 4380; https://doi.org/10.3390/molecules26144380
Received: 30 June 2021 / Revised: 14 July 2021 / Accepted: 15 July 2021 / Published: 20 July 2021
Low-grade chronic inflammation (LGCI) and oxidative stress act as cooperative and synergistic partners in the pathogenesis of a wide variety of diseases. Polyphenols, including anthocyanins, are involved in regulating the inflammatory state and activating the endogenous antioxidant defenses. Anthocyanins’ effects on inflammatory markers are promising and may have the potential to exert an anti-inflammatory effect in vitro and in vivo. Therefore, translating these research findings into clinical practice would effectively contribute to the prevention and treatment of chronic disease. The present narrative review summarizes the results of clinical studies from the last 5 years in the context of the anti-inflammatory and anti-oxidative role of anthocyanins in both health and disease. There is evidence to indicate that anthocyanins supplementation in the regulation of pro-inflammatory markers among the healthy and chronic disease population. Although the inconsistencies between the result of randomized control trials (RCTs) and meta-analyses were also observed. Regarding anthocyanins’ effects on inflammatory markers, there is a need for long-term clinical trials allowing for the quantifiable progression of inflammation. The present review can help clinicians and other health care professionals understand the importance of anthocyanins use in patients with chronic diseases. View Full-Text
Keywords: anthocyanins; inflammation; oxidative stress anthocyanins; inflammation; oxidative stress
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MDPI and ACS Style

Kozłowska, A.; Dzierżanowski, T. Targeting Inflammation by Anthocyanins as the Novel Therapeutic Potential for Chronic Diseases: An Update. Molecules 2021, 26, 4380. https://doi.org/10.3390/molecules26144380

AMA Style

Kozłowska A, Dzierżanowski T. Targeting Inflammation by Anthocyanins as the Novel Therapeutic Potential for Chronic Diseases: An Update. Molecules. 2021; 26(14):4380. https://doi.org/10.3390/molecules26144380

Chicago/Turabian Style

Kozłowska, Aleksandra, and Tomasz Dzierżanowski. 2021. "Targeting Inflammation by Anthocyanins as the Novel Therapeutic Potential for Chronic Diseases: An Update" Molecules 26, no. 14: 4380. https://doi.org/10.3390/molecules26144380

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