Target Identification Using Homopharma and Network-Based Methods for Predicting Compounds Against Dengue Virus-Infected Cells
Abstract
:1. Introduction
2. Results and Discussion
2.1. Similar Compounds of Phenolic Lipids for Predicting Target
2.2. Network-Based Construction and Centrality Analysis
2.3. Prediction of DENV Related Target
2.4. Viral Target for Phenolic Lipid Compounds
2.5. Human Protein Target Annotation
3. Materials and Methods
3.1. Data Collection
3.2. Related Target Evaluation
3.3. Network-Based Construction and Analysis
3.4. Identification of Targets Aassociated with DENV
3.5. Target Annotation
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Sample Availability: Samples are not available from the authors. |
Phenolic Lipid Compounds | Similar Compounds |
---|---|
Anacardic acid | 223 |
Cardol | 311 |
Cardanol | 447 |
Property | DenvIntS Network (Whole Network) |
---|---|
Nodes | 488 |
Edges | 2523 |
Average degree | 10.340 |
Nodes per edge | 0.193 |
Diameter | 5 |
Average clustering coefficient | 0.45 |
Average path length | 2.842 |
Graph density | 0.021 |
Node Property (In Average) | All Nodes | Human Protein Nodes | DENV Protein Nodes |
---|---|---|---|
Degree | 10.340 | 9.142 | 67.600 |
Eigencentrality | 0.116 | 0.113 | 0.238 |
CC | 0.357 | 0.356 | 0.410 |
BC | 0.004 | 0.002 | 0.108 |
Clustering coefficient | 0.315 | 0.320 | 0.054 |
Number of triangles | 83.195 | 82.797 | 102.200 |
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Share and Cite
Hengphasatporn, K.; Plaimas, K.; Suratanee, A.; Wongsriphisant, P.; Yang, J.-M.; Shigeta, Y.; Chavasiri, W.; Boonyasuppayakorn, S.; Rungrotmongkol, T. Target Identification Using Homopharma and Network-Based Methods for Predicting Compounds Against Dengue Virus-Infected Cells. Molecules 2020, 25, 1883. https://doi.org/10.3390/molecules25081883
Hengphasatporn K, Plaimas K, Suratanee A, Wongsriphisant P, Yang J-M, Shigeta Y, Chavasiri W, Boonyasuppayakorn S, Rungrotmongkol T. Target Identification Using Homopharma and Network-Based Methods for Predicting Compounds Against Dengue Virus-Infected Cells. Molecules. 2020; 25(8):1883. https://doi.org/10.3390/molecules25081883
Chicago/Turabian StyleHengphasatporn, Kowit, Kitiporn Plaimas, Apichat Suratanee, Peemapat Wongsriphisant, Jinn-Moon Yang, Yasuteru Shigeta, Warinthorn Chavasiri, Siwaporn Boonyasuppayakorn, and Thanyada Rungrotmongkol. 2020. "Target Identification Using Homopharma and Network-Based Methods for Predicting Compounds Against Dengue Virus-Infected Cells" Molecules 25, no. 8: 1883. https://doi.org/10.3390/molecules25081883