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Open AccessArticle

Mannoside-Modified Branched Gold Nanoparticles for Photothermal Therapy to MDA-MB-231 Cells

1
Department of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
3
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan
4
Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung 402, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2020, 25(8), 1853; https://doi.org/10.3390/molecules25081853
Received: 20 March 2020 / Revised: 14 April 2020 / Accepted: 15 April 2020 / Published: 17 April 2020
(This article belongs to the Section Macromolecular Chemistry)
Recently, gold nanoparticles (Au NPs) have been used to study the treatment of malignant tumors due to their higher biocompatibility and lesser toxicity. In addition, they can be excited through a specific wavelength to produce oscillating plasmonic photothermal therapy (PPTT) on the basis of the localized surface plasma resonance (LSPR) effect. Au NPs can be heated to kill cancer cells in specific parts of the body in a noninvasive manner. In this study, branched gold nanoparticles (BAu NPs) were prepared by mixing HAuCl4 in a 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) buffer solution in a molar ratio of 1:2000. The UV–vis absorption peak was detected in the range of 700–1000 nm. Subsequently, BAu NPs were chemically linked to a thiol-modified mannoside molecule via a stable sulfur–Au covalent bond ([email protected] NPs). Due to the presence of abundant mannose receptors on human-breast-cancer cells, MDA-MB-231, [email protected] NPs were found to be abundant inside cancer cells. After irradiating the [email protected] NP-laden MDA-MB231 switch with a near-infrared (NIR) laser at 808 nm wavelength, the photothermal-conversion effect raised the surface temperature of [email protected] NPs, thus inducing cell death. Our experiment results demonstrated the advantages of applying [email protected] NPs in inducing cell death in MDA-MB-231. View Full-Text
Keywords: branched gold nanoparticles; photothermal therapy; near-infrared (NIR) laser; MDA-MB-231 cell; mannose receptor branched gold nanoparticles; photothermal therapy; near-infrared (NIR) laser; MDA-MB-231 cell; mannose receptor
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MDPI and ACS Style

Lin, H.-C.; Hsu, K.-F.; Lai, C.-L.; Wu, T.-C.; Chen, H.-F.; Lai, C.-H. Mannoside-Modified Branched Gold Nanoparticles for Photothermal Therapy to MDA-MB-231 Cells. Molecules 2020, 25, 1853.

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