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Open AccessArticle

Anti-Virulence Potential and In Vivo Toxicity of Persicaria maculosa and Bistorta officinalis Extracts

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Faculty of Biology, University of Belgrade, Studentski trg 16, 11158 Belgrade, Serbia
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Institute of General and Physical Chemistry, Studentski trg 12/V, 11158 Belgrade, Serbia
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Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, Serbia
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Faculty of Science, University of Novi Sad, Dositeja Obradovića 2, 21000 Novi Sad, Serbia
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Author to whom correspondence should be addressed.
Molecules 2020, 25(8), 1811; https://doi.org/10.3390/molecules25081811
Received: 21 March 2020 / Revised: 9 April 2020 / Accepted: 13 April 2020 / Published: 15 April 2020
(This article belongs to the Section Natural Products Chemistry)
Many traditional remedies represent potential candidates for integration with modern medical practice, but credible data on their activities are often scarce. For the first time, the anti-virulence potential and the safety for human use of the ethanol extracts of two medicinal plants, Persicaria maculosa (PEM) and Bistorta officinalis (BIO), have been addressed. Ethanol extracts of both plants exhibited anti-virulence activity against the medically important opportunistic pathogen Pseudomonas aeruginosa. At the subinhibitory concentration of 50 µg/mL, the extracts demonstrated a maximal inhibitory effect (approx. 50%) against biofilm formation, the highest reduction of pyocyanin production (47% for PEM and 59% for BIO) and completely halted the swarming motility of P. aeruginosa. Both extracts demonstrated better anti-quorum sensing and antibiofilm activities, and a better ability to interfere with LasR receptor, than the tested dominant extracts’ constituents. The bioactive concentrations of the extracts were not toxic in the zebrafish model system. This study represents an initial step towards the integration of P. maculosa and B. officinalis for use in the treatment of Pseudomonas infections. View Full-Text
Keywords: Persicaria maculosa; Bistorta officinalis; antibiofilm activity; anti-quorum sensing activity; zebrafish Persicaria maculosa; Bistorta officinalis; antibiofilm activity; anti-quorum sensing activity; zebrafish
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MDPI and ACS Style

Jovanović, M.; Morić, I.; Nikolić, B.; Pavić, A.; Svirčev, E.; Šenerović, L.; Mitić-Ćulafić, D. Anti-Virulence Potential and In Vivo Toxicity of Persicaria maculosa and Bistorta officinalis Extracts. Molecules 2020, 25, 1811.

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