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Open AccessReview

Pharmacological Update Properties of Aloe Vera and its Major Active Constituents

Department of Pharmacology, Pharmacognosy and Botany, Faculty of Pharmacy, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain
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Molecules 2020, 25(6), 1324; https://doi.org/10.3390/molecules25061324
Received: 24 February 2020 / Revised: 9 March 2020 / Accepted: 11 March 2020 / Published: 13 March 2020
Aloe vera has been traditionally used to treat skin injuries (burns, cuts, insect bites, and eczemas) and digestive problems because its anti-inflammatory, antimicrobial, and wound healing properties. Research on this medicinal plant has been aimed at validating traditional uses and deepening the mechanism of action, identifying the compounds responsible for these activities. The most investigated active compounds are aloe-emodin, aloin, aloesin, emodin, and acemannan. Likewise, new actions have been investigated for Aloe vera and its active compounds. This review provides an overview of current pharmacological studies (in vitro, in vivo, and clinical trials), written in English during the last six years (2014–2019). In particular, new pharmacological data research has shown that most studies refer to anti-cancer action, skin and digestive protective activity, and antimicrobial properties. Most recent works are in vitro and in vivo. Clinical trials have been conducted just with Aloe vera, but not with isolated compounds; therefore, it would be interesting to study the clinical effect of relevant metabolites in different human conditions and pathologies. The promising results of these studies in basic research encourage a greater number of clinical trials to test the clinical application of Aloe vera and its main compounds, particularly on bone protection, cancer, and diabetes. View Full-Text
Keywords: Aloe vera; pharmacology; extracts; isolated compounds Aloe vera; pharmacology; extracts; isolated compounds
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MDPI and ACS Style

Sánchez, M.; González-Burgos, E.; Iglesias, I.; Gómez-Serranillos, M.P. Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. Molecules 2020, 25, 1324. https://doi.org/10.3390/molecules25061324

AMA Style

Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. Molecules. 2020; 25(6):1324. https://doi.org/10.3390/molecules25061324

Chicago/Turabian Style

Sánchez, Marta; González-Burgos, Elena; Iglesias, Irene; Gómez-Serranillos, M. P. 2020. "Pharmacological Update Properties of Aloe Vera and its Major Active Constituents" Molecules 25, no. 6: 1324. https://doi.org/10.3390/molecules25061324

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