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Open AccessFeature PaperArticle

On the Formation and Stability of Chitosan/Hyaluronan-Based Complex Coacervates

1
Department of Life Sciences, University of Trieste, Via L. Giorgieri 5, I-34127 Trieste, Italy
2
Elettra-Sincrotrone Trieste S.C.p.A., s.s. 14 km 163,500, I-34149 Basovizza, I-34127 Trieste, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Ivan Donati
Molecules 2020, 25(5), 1071; https://doi.org/10.3390/molecules25051071
Received: 28 January 2020 / Revised: 18 February 2020 / Accepted: 25 February 2020 / Published: 27 February 2020
(This article belongs to the Special Issue Novel Polysaccharide Materials)
This contribution is aimed at extending our previous findings on the formation and stability of chitosan/hyaluronan-based complex coacervates. Colloids are herewith formed by harnessing electrostatic interactions between the two polyelectrolytes. The presence of tiny amounts of the multivalent anion tripolyphosphate (TPP) in the protocol synthesis serves as an adjuvant “point-like” cross-linker for chitosan. Hydrochloride chitosans at different viscosity average molar mass, M v ¯ , in the range 10,000–400,000 g/mol, and fraction of acetylated units, FA, (0.16, 0.46 and 0.63) were selected to fabricate a large library of formulations. Concepts such as coacervate size, surface charge and homogeneity in relation to chitosan variables are herein disclosed. The stability of coacervates in Phosphate Buffered Saline (PBS) was verified by means of scattering techniques, i.e., Dynamic Light Scattering (DLS) and Small-Angle X-ray Scattering (SAXS). The conclusions from this set of experiments are the following: (i) a subtle equilibrium between chitosan FA and M v ¯ does exist in ensuring colloidal stability; (ii) once diluted in PBS, osmotic swelling-driven forces trigger the enlargement of the polymeric mesh with an ensuing increase of coacervate size and porosity. View Full-Text
Keywords: chitosan; hyaluronan; complex coacervation; dissolution/aggregation stability; Small Angle X-ray Scattering (SAXS) chitosan; hyaluronan; complex coacervation; dissolution/aggregation stability; Small Angle X-ray Scattering (SAXS)
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MDPI and ACS Style

Furlani, F.; Parisse, P.; Sacco, P. On the Formation and Stability of Chitosan/Hyaluronan-Based Complex Coacervates. Molecules 2020, 25, 1071. https://doi.org/10.3390/molecules25051071

AMA Style

Furlani F, Parisse P, Sacco P. On the Formation and Stability of Chitosan/Hyaluronan-Based Complex Coacervates. Molecules. 2020; 25(5):1071. https://doi.org/10.3390/molecules25051071

Chicago/Turabian Style

Furlani, Franco; Parisse, Pietro; Sacco, Pasquale. 2020. "On the Formation and Stability of Chitosan/Hyaluronan-Based Complex Coacervates" Molecules 25, no. 5: 1071. https://doi.org/10.3390/molecules25051071

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