Topical Administration of Terpenes Encapsulated in Nanostructured Lipid-Based Systems
Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska St 24, 31-155 Kraków, Poland
Academic Editors: Pavel B. Drasar and Vladimir A. Khripach
Molecules 2020, 25(23), 5758; https://doi.org/10.3390/molecules25235758
Received: 25 October 2020
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Revised: 27 November 2020
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Accepted: 3 December 2020
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Published: 7 December 2020
(This article belongs to the Special Issue Terpenes and Terpene Derivatives)
Terpenes are a group of phytocompounds that have been used in medicine for decades owing to their significant role in human health. So far, they have been examined for therapeutic purposes as antibacterial, anti-inflammatory, antitumoral agents, and the clinical potential of this class of compounds has been increasing continuously as a source of pharmacologically interesting agents also in relation to topical administration. Major difficulties in achieving sustained delivery of terpenes to the skin are connected with their low solubility and stability, as well as poor cell penetration. In order to overcome these disadvantages, new delivery technologies based on nanostructures are proposed to improve bioavailability and allow controlled release. This review highlights the potential properties of terpenes loaded in several types of lipid-based nanocarriers (liposomes, solid lipid nanoparticles, and nanostructured lipid carriers) used to overcome free terpenes’ form limitations and potentiate their therapeutic properties for topical administration.
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Keywords:
terpenes; terpenoids; lipid nanoparticles; nanostructured lipid carriers; topical administration; lipid-based systems
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MDPI and ACS Style
Lasoń, E. Topical Administration of Terpenes Encapsulated in Nanostructured Lipid-Based Systems. Molecules 2020, 25, 5758. https://doi.org/10.3390/molecules25235758
AMA Style
Lasoń E. Topical Administration of Terpenes Encapsulated in Nanostructured Lipid-Based Systems. Molecules. 2020; 25(23):5758. https://doi.org/10.3390/molecules25235758
Chicago/Turabian StyleLasoń, Elwira. 2020. "Topical Administration of Terpenes Encapsulated in Nanostructured Lipid-Based Systems" Molecules 25, no. 23: 5758. https://doi.org/10.3390/molecules25235758
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