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Article

Mucuna pruriens Administration Minimizes Neuroinflammation and Shows Anxiolytic, Antidepressant and Slimming Effects in Obese Rats

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Experimental Nutrition Laboratory, Department of Nutrition, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Brazil
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Department of Food Technology, Federal Institute of Sertão Pernambucano, Rod. BR 407 km 08, s/n-Jardim São Paulo, Petrolina 56314-522, Brazil
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Department of Psychology, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Brazil
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Pathology Laboratory, Department of Pathology, Federal University of Minas Gerais, Av. Pres. Antônio Carlos, n.6627-Pampulha, Belo Horizonte 31270-901, Brazil
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Department of Physiology and Pathology, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Brazil
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Pharmaceutical Technology Laboratory, Department of Pharmaceutical Sciences, Federal University of Paraíba, Cidade Universitária, s/n-Castelo Branco III, João Pessoa 58051-085, Brazil
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Laboratory Neuronutrition and Metabolic Disorders, Higher Technological Institute of Tacámbaro, Av. Tecnológico 201, Tecario, Tacámbaro 61651, Mexico
*
Author to whom correspondence should be addressed.
Molecules 2020, 25(23), 5559; https://doi.org/10.3390/molecules25235559
Received: 17 October 2020 / Revised: 8 November 2020 / Accepted: 14 November 2020 / Published: 26 November 2020
(This article belongs to the Section Natural Products Chemistry)
This study evaluated the effect of Mucuna pruriens (MP) administration on neuroinflammation and behavioral and murinometric parameters in obese rats. Proximate composition, oligosaccharide and phenolic compound profile of MP were determined. Wistar adult male rats were randomized into healthy (HG) and obese group (OG). The HG consumed a control chow diet while OG consumed a cafeteria diet for eight weeks. Then, they were subdivided into: Healthy (HG); Healthy with MP administration (HGMP); Obese (OG); Obese with MP administration (OGMP), with the consumption of the respective diets remaining for another eight weeks, in addition to gavage with MP extract to supplemented groups (750 mg/kg weight). MP presented a composition rich in proteins and phenolic compounds, especially catechin, in addition to 1-kestose and levodopa. Supplementation reduced food intake, body weight, and thoracic and abdominal circumferences in obese rats. MP showed anxiolytic and antidepressant effects and reduced morphological damage and expression of interleukin 6 in the hippocampus of obese rats. MP treatment showed satietogenic, slimming, anxiolytic and antidepressant effects, besides to minimizing hippocampal neuroinflammation in obese rats. Our results demonstrated the potential anti-obesity of MP which are probably related to the high content of bioactive compounds present in this plant extract. View Full-Text
Keywords: cafeteria diet; bioactive compounds; interleukin 6; neurobehavior; obesity; weigh loss cafeteria diet; bioactive compounds; interleukin 6; neurobehavior; obesity; weigh loss
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MDPI and ACS Style

Tavares, R.l.; Vasconcelos, M.H.A.d.; Dutra, M.L.d.V.; D’Oliveira, A.B.; Lima, M.d.S.; Salvadori, M.G.d.S.S.; Pereira, R.d.A.; Alves, A.F.; Nascimento, Y.M.d.; Tavares, J.F.; Guzman-Quevedo, O.; Aquino, J.d.S. Mucuna pruriens Administration Minimizes Neuroinflammation and Shows Anxiolytic, Antidepressant and Slimming Effects in Obese Rats. Molecules 2020, 25, 5559. https://doi.org/10.3390/molecules25235559

AMA Style

Tavares Rl, Vasconcelos MHAd, Dutra MLdV, D’Oliveira AB, Lima MdS, Salvadori MGdSS, Pereira RdA, Alves AF, Nascimento YMd, Tavares JF, Guzman-Quevedo O, Aquino JdS. Mucuna pruriens Administration Minimizes Neuroinflammation and Shows Anxiolytic, Antidepressant and Slimming Effects in Obese Rats. Molecules. 2020; 25(23):5559. https://doi.org/10.3390/molecules25235559

Chicago/Turabian Style

Tavares, Renata leite, Maria Helena Araújo de Vasconcelos, Maria Letícia da Veiga Dutra, Aline Barbosa D’Oliveira, Marcos dos Santos Lima, Mirian Graciela da Silva Stiebbe Salvadori, Ramon de Alencar Pereira, Adriano Francisco Alves, Yuri Mangueira do Nascimento, Josean Fechine Tavares, Omar Guzman-Quevedo, and Jailane de Souza Aquino. 2020. "Mucuna pruriens Administration Minimizes Neuroinflammation and Shows Anxiolytic, Antidepressant and Slimming Effects in Obese Rats" Molecules 25, no. 23: 5559. https://doi.org/10.3390/molecules25235559

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