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Article

Photoproducts of the Photodynamic Therapy Agent Verteporfin Identified via Laser Interfaced Mass Spectrometry

Department of Chemistry, University of York, Heslington York YO10 5DD, UK
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Author to whom correspondence should be addressed.
Academic Editor: Anan Yaghmur
Molecules 2020, 25(22), 5280; https://doi.org/10.3390/molecules25225280
Received: 14 October 2020 / Revised: 8 November 2020 / Accepted: 9 November 2020 / Published: 12 November 2020
Verteporfin, a free base benzoporphyrin derivative monoacid ring A, is a photosensitizing drug for photodynamic therapy (PDT) used in the treatment of the wet form of macular degeneration and activated by red light of 689 nm. Here, we present the first direct study of its photofragmentation channels in the gas phase, conducted using a laser interfaced mass spectrometer across a broad photoexcitation range from 250 to 790 nm. The photofragmentation channels are compared with the collision-induced dissociation (CID) products revealing similar dissociation pathways characterized by the loss of the carboxyl and ester groups. Complementary solution-phase photolysis experiments indicate that photobleaching occurs in verteporfin in acetonitrile; a notable conclusion, as photoinduced activity in Verteporfin was not thought to occur in homogenous solvent conditions. These results provide unique new information on the thermal break-down products and photoproducts of this light-triggered drug. View Full-Text
Keywords: verteporfin; photosensitizer; photo dynamic therapy; PDT; photofragments; photofragmentation channels; mass spectrometry; laser spectroscopy; photolysis verteporfin; photosensitizer; photo dynamic therapy; PDT; photofragments; photofragmentation channels; mass spectrometry; laser spectroscopy; photolysis
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MDPI and ACS Style

Furlan, C.; Berenbeim, J.A.; Dessent, C.E.H. Photoproducts of the Photodynamic Therapy Agent Verteporfin Identified via Laser Interfaced Mass Spectrometry. Molecules 2020, 25, 5280. https://doi.org/10.3390/molecules25225280

AMA Style

Furlan C, Berenbeim JA, Dessent CEH. Photoproducts of the Photodynamic Therapy Agent Verteporfin Identified via Laser Interfaced Mass Spectrometry. Molecules. 2020; 25(22):5280. https://doi.org/10.3390/molecules25225280

Chicago/Turabian Style

Furlan, Chris, Jacob A. Berenbeim, and Caroline E. H. Dessent. 2020. "Photoproducts of the Photodynamic Therapy Agent Verteporfin Identified via Laser Interfaced Mass Spectrometry" Molecules 25, no. 22: 5280. https://doi.org/10.3390/molecules25225280

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