Small Molecules Targeting Biological Clock; A Novel Prospective for Anti-Cancer Drugs
Department of Biotechnology, University of Rijeka, 51000 Rijeka, Croatia
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Academic Editors: Krešimir Pavelić and Sandra Kraljević Pavelić
Molecules 2020, 25(21), 4937; https://doi.org/10.3390/molecules25214937
Received: 2 October 2020
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Revised: 23 October 2020
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Accepted: 24 October 2020
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Published: 26 October 2020
(This article belongs to the Special Issue Translational Approach to Antitumor Drugs)
The circadian rhythms are an intrinsic timekeeping system that regulates numerous physiological, biochemical, and behavioral processes at intervals of approximately 24 h. By regulating such processes, the circadian rhythm allows organisms to anticipate and adapt to continuously changing environmental conditions. A growing body of evidence shows that disruptions to the circadian rhythm can lead to various disorders, including cancer. Recently, crucial knowledge has arisen regarding the essential features that underlie the overt circadian rhythm and its influence on physiological outputs. This knowledge suggests that specific small molecules can be utilized to control the circadian rhythm. It has been discovered that these small molecules can regulate circadian-clock-related disorders such as metabolic, cardiovascular, inflammatory, as well as cancer. This review examines the potential use of small molecules for developing new drugs, with emphasis placed on recent progress that has been made regarding the identification of small-molecule clock modulators and their potential use in treating cancer.
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Keywords:
circadian rhythm; biological clock; cancer; small molecules; anticancer drugs
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MDPI and ACS Style
Rahman, S.; Wittine, K.; Sedić, M.; Markova-Car, E.P. Small Molecules Targeting Biological Clock; A Novel Prospective for Anti-Cancer Drugs. Molecules 2020, 25, 4937. https://doi.org/10.3390/molecules25214937
AMA Style
Rahman S, Wittine K, Sedić M, Markova-Car EP. Small Molecules Targeting Biological Clock; A Novel Prospective for Anti-Cancer Drugs. Molecules. 2020; 25(21):4937. https://doi.org/10.3390/molecules25214937
Chicago/Turabian StyleRahman, Sadia, Karlo Wittine, Mirela Sedić, and Elitza P. Markova-Car. 2020. "Small Molecules Targeting Biological Clock; A Novel Prospective for Anti-Cancer Drugs" Molecules 25, no. 21: 4937. https://doi.org/10.3390/molecules25214937
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