Next Article in Journal
Comparing Fragment Binding Poses Prediction Using HSP90 as a Key Study: When Bound Water Makes the Difference
Previous Article in Journal
Sprouts vs. Microgreens as Novel Functional Foods: Variation of Nutritional and Phytochemical Profiles and Their In vitro Bioactive Properties
Open AccessReview

Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases

Department of Biotechnology, College of Life Sciences & Biotechnology, BK21-PLUS, Korea University, Seoul 02846, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2020, 25(20), 4649; https://doi.org/10.3390/molecules25204649
Received: 7 August 2020 / Revised: 29 September 2020 / Accepted: 3 October 2020 / Published: 12 October 2020
Aging gradually decreases cellular biological functions and increases the risk of age-related diseases. Cancer, type 2 diabetes mellitus, cardiovascular disease, and neurological disorders are commonly classified as age-related diseases that can affect the lifespan and health of individuals. Aging is a complicated and sophisticated biological process involving damage to biochemical macromolecules including DNA, proteins, and cellular organelles such as mitochondria. Aging causes multiple alterations in biological processes including energy metabolism and nutrient sensing, thus reducing cell proliferation and causing cellular senescence. Among the polyphenolic phytochemicals, resveratrol is believed to reduce the negative effects of the aging process through its multiple biological activities. Resveratrol increases the lifespan of several model organisms by regulating oxidative stress, energy metabolism, nutrient sensing, and epigenetics, primarily by activating sirtuin 1. This review summarizes the most important biological mechanisms of aging, and the ability of resveratrol to prevent age-related diseases. View Full-Text
Keywords: aging; age-related diseases; resveratrol aging; age-related diseases; resveratrol
Show Figures

Figure 1

MDPI and ACS Style

Pyo, I.S.; Yun, S.; Yoon, Y.E.; Choi, J.-W.; Lee, S.-J. Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases. Molecules 2020, 25, 4649. https://doi.org/10.3390/molecules25204649

AMA Style

Pyo IS, Yun S, Yoon YE, Choi J-W, Lee S-J. Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases. Molecules. 2020; 25(20):4649. https://doi.org/10.3390/molecules25204649

Chicago/Turabian Style

Pyo, In S.; Yun, Suyeon; Yoon, Ye E.; Choi, Jung-Won; Lee, Sung-Joon. 2020. "Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases" Molecules 25, no. 20: 4649. https://doi.org/10.3390/molecules25204649

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop