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Review

The Role of Resveratrol in Mammalian Reproduction

1
Department of Agricultural and Environmental Sciences, University of Milan, 20133 Milano, Italy
2
Department of Health, Animal Science and Food Safety, University of Milan, 20133 Milano, Italy
3
Department of Veterinary Medicine, University of Perugia, 06126 Perugia, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Norbert Latruffe
Molecules 2020, 25(19), 4554; https://doi.org/10.3390/molecules25194554
Received: 31 August 2020 / Revised: 20 September 2020 / Accepted: 30 September 2020 / Published: 5 October 2020
Resveratrol is one of the most investigated natural polyphenolic compounds and is contained in more than 70 types of plants and in red wine. The widespread interest in this polyphenol derives from its antioxidant, anti-inflammatory and anti-aging properties. Several studies have established that resveratrol regulates animal reproduction. However, the mechanisms of action and the potential therapeutic effects are still unclear. This review aims to clarify the role of resveratrol in male and female reproductive functions, with a focus on animals of veterinary interest. In females, resveratrol has been considered as a phytoestrogen due to its capacity to modulate ovarian function and steroidogenesis via sirtuins, SIRT1 in particular. Resveratrol has also been used to enhance aged oocyte quality and as a gametes cryo-protectant with mainly antioxidant and anti-apoptotic effects. In males, resveratrol enhances testes function and spermatogenesis through activation of the AMPK pathway. Furthermore, resveratrol has been supplemented to semen extenders, improving the preservation of sperm quality. In conclusion, resveratrol has potentially beneficial effects for ameliorating ovarian and testes function. View Full-Text
Keywords: polyphenols; reproduction; phytoestrogens; ovary function; sirtuin; testis function; spermatozoa; cryopreservation; sperm quality; oocyte quality polyphenols; reproduction; phytoestrogens; ovary function; sirtuin; testis function; spermatozoa; cryopreservation; sperm quality; oocyte quality
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MDPI and ACS Style

Pasquariello, R.; Verdile, N.; Brevini, T.A.L.; Gandolfi, F.; Boiti, C.; Zerani, M.; Maranesi, M. The Role of Resveratrol in Mammalian Reproduction. Molecules 2020, 25, 4554. https://doi.org/10.3390/molecules25194554

AMA Style

Pasquariello R, Verdile N, Brevini TAL, Gandolfi F, Boiti C, Zerani M, Maranesi M. The Role of Resveratrol in Mammalian Reproduction. Molecules. 2020; 25(19):4554. https://doi.org/10.3390/molecules25194554

Chicago/Turabian Style

Pasquariello, Rolando, Nicole Verdile, Tiziana A.L. Brevini, Fulvio Gandolfi, Cristiano Boiti, Massimo Zerani, and Margherita Maranesi. 2020. "The Role of Resveratrol in Mammalian Reproduction" Molecules 25, no. 19: 4554. https://doi.org/10.3390/molecules25194554

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