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Article

Plant Milking Technology—An Innovative and Sustainable Process to Produce Highly Active Extracts from Plant Roots

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Clariant Active Ingredients, 195 Route d′Espagne, 31000 Toulouse, France
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Plant Advanced Technologies, 19 Avenue de la Forêt de Haye, 54500 Vandoeuvre, France
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Author to whom correspondence should be addressed.
Academic Editor: Panagiotis Zoumpoulakis
Molecules 2020, 25(18), 4162; https://doi.org/10.3390/molecules25184162
Received: 6 July 2020 / Revised: 1 September 2020 / Accepted: 7 September 2020 / Published: 11 September 2020
(This article belongs to the Special Issue Bioactive Compounds with Applications in Health and Food)
We have used an original technology (Plant Milking Technology) based on aeroponic cultivation of plants associated with the gentle recovery of active ingredients from roots. Extraction of bioactive molecules was achieved by soaking the roots, still attached to the living plants, into a nontoxic solvent for a 2 h period. This nondestructive recovery process allows using the same root biomass for successive harvesting dates, in a recyclable way. We have applied this technology to Morus alba L. (mulberry tree), an emblematic tree of the Traditional Chinese Medicine (TCM). Trees were aeroponically grown in large-scale devices (100 m2) and were submitted to nitrogen deprivation to increase the content in active molecules (prenylated flavonoids). The Plant Milking technology applied to Morus alba L. allowed to produce an extract enriched in prenylated compounds (18-fold increase when compared to commercial root extract). Prenylated flavonoids (moracenin A and B, kuwanon C, wittiorumin F, morusin) presented a high affinity for the aged-associated collagenase enzyme, which was confirmed by activity inhibition. In accordance, M. alba extract presents efficient properties to regulate the skin matrisome, which is critical during skin aging. The benefits have been especially confirmed in vivo on wrinkle reduction, in a clinical study that involved aged women. Plant Milking technology is an optimal solution to produce active ingredients from plant roots, including trees, that meet both customer expectations around sustainability, as well as the need for an efficient production system for biotechnologists. View Full-Text
Keywords: natural compound; root; sustainability; moracenin; Morus alba L.; prenylated flavonoids natural compound; root; sustainability; moracenin; Morus alba L.; prenylated flavonoids
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MDPI and ACS Style

Chajra, H.; Salwinski, A.; Guillaumin, A.; Mignard, B.; Hannewald, P.; Duriot, L.; Warnault, P.; Guillet-Claude, C.; Fréchet, M.; Bourgaud, F. Plant Milking Technology—An Innovative and Sustainable Process to Produce Highly Active Extracts from Plant Roots. Molecules 2020, 25, 4162. https://doi.org/10.3390/molecules25184162

AMA Style

Chajra H, Salwinski A, Guillaumin A, Mignard B, Hannewald P, Duriot L, Warnault P, Guillet-Claude C, Fréchet M, Bourgaud F. Plant Milking Technology—An Innovative and Sustainable Process to Produce Highly Active Extracts from Plant Roots. Molecules. 2020; 25(18):4162. https://doi.org/10.3390/molecules25184162

Chicago/Turabian Style

Chajra, Hanane, Aleksander Salwinski, Agnès Guillaumin, Benoit Mignard, Paul Hannewald, Léonor Duriot, Pierre Warnault, Carine Guillet-Claude, Mathilde Fréchet, and Frédéric Bourgaud. 2020. "Plant Milking Technology—An Innovative and Sustainable Process to Produce Highly Active Extracts from Plant Roots" Molecules 25, no. 18: 4162. https://doi.org/10.3390/molecules25184162

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