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Article

Meroterpenoids from the Fungus Ganoderma sinensis and First Absolute Configuration Clarification of Zizhine H

1
School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China
2
College of Pharmaceutical Sciences, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2020, 25(1), 158; https://doi.org/10.3390/molecules25010158
Received: 30 November 2019 / Revised: 27 December 2019 / Accepted: 27 December 2019 / Published: 31 December 2019
(This article belongs to the Section Natural Products Chemistry)
Five new meroterpenoids, zizhines P-S and U (14,7), together with two known meroterpenoids (5 and 6) were isolated from Ganoderma sinensis. Their structures including absolute configurations were assigned by using spectroscopic, computational, and chemical methods. Racemics zizhines P and Q were purified by HPLC on chiral phase. Biological evaluation found that 4, 5 and 6 are cytotoxic toward human cancer cells (A549, BGC-823, Kyse30) with IC50 values in the range of 63.43–80.83 μM towards A549, 59.2 ± 2.73 μM and 64.25 ± 0.37 μM towards BGC-823, 76.28 ± 1.93 μM and 85.42 ± 2.82 μM towards Kyse30. View Full-Text
Keywords: Ganoderma sinensis; fungus; meroterpenoids; zizhines P-S and U; cytotoxic activity Ganoderma sinensis; fungus; meroterpenoids; zizhines P-S and U; cytotoxic activity
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MDPI and ACS Style

Yin, Y.-J.; Huang, D.-L.; Qiu, B.; Cai, D.; Zhang, J.-J.; Wang, S.-X.; Qin, D.-P.; Cheng, Y.-X. Meroterpenoids from the Fungus Ganoderma sinensis and First Absolute Configuration Clarification of Zizhine H. Molecules 2020, 25, 158. https://doi.org/10.3390/molecules25010158

AMA Style

Yin Y-J, Huang D-L, Qiu B, Cai D, Zhang J-J, Wang S-X, Qin D-P, Cheng Y-X. Meroterpenoids from the Fungus Ganoderma sinensis and First Absolute Configuration Clarification of Zizhine H. Molecules. 2020; 25(1):158. https://doi.org/10.3390/molecules25010158

Chicago/Turabian Style

Yin, Yan-Jiao; Huang, Dan-Ling; Qiu, Bin; Cai, Dan; Zhang, Jiao-Jiao; Wang, Shao-Xiang; Qin, Da-Peng; Cheng, Yong-Xian. 2020. "Meroterpenoids from the Fungus Ganoderma sinensis and First Absolute Configuration Clarification of Zizhine H" Molecules 25, no. 1: 158. https://doi.org/10.3390/molecules25010158

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