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Review

Secondary Metabolites from Gorgonian Corals of the Genus Eunicella: Structural Characterizations, Biological Activities, and Synthetic Approaches

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Department of Biotechnology, University of Rijeka, Radmile Matejčić 2, 51000 Rijeka, Croatia
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Department of Physics and Centre for Micro- and Nanosciences and Technologies, University of Rijeka, Radmile Matejčić 2, 51000 Rijeka, Croatia
3
Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources (LG2A) UMR CNRS 7378—Institut de Chimie de Picardie FR 3085, Université de Picardie Jules Verne, 33 rue Saint Leu, FR-80039 Amiens CEDEX, France
*
Authors to whom correspondence should be addressed.
Academic Editor: Paula B. Andrade
Molecules 2020, 25(1), 129; https://doi.org/10.3390/molecules25010129
Received: 9 December 2019 / Revised: 24 December 2019 / Accepted: 26 December 2019 / Published: 28 December 2019
(This article belongs to the Special Issue Translational Approach to Antitumor Drugs)
Gorgonian corals, which belong to the genus Eunicella, are known as natural sources of diverse compounds with unique structural characteristics and interesting bioactivities both in vitro and in vivo. This review is focused primarily on the secondary metabolites isolated from various Eunicella species. The chemical structures of 64 compounds were divided into three main groups and comprehensively presented: a) terpenoids, b) sterols, and c) alkaloids and nucleosides. The observed biological activities of depicted metabolites with an impact on cytotoxic, anti-inflammatory, and antimicrobial activities were reviewed. The most promising biological activities of certain metabolites point to potential candidates for further development in pharmaceutical, cosmetic, and other industries, and are highlighted. Total synthesis or the synthetic approaches towards the desired skeletons or natural products are also summarized. View Full-Text
Keywords: Eunicella genus; eunicellin-type diterpenes; sterols; nitrogenated compounds; cytotoxic; anti-inflammatory; antimicrobial; synthetic approaches Eunicella genus; eunicellin-type diterpenes; sterols; nitrogenated compounds; cytotoxic; anti-inflammatory; antimicrobial; synthetic approaches
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MDPI and ACS Style

Matulja, D.; Kolympadi Markovic, M.; Ambrožić, G.; Laclef, S.; Pavelić, S.K.; Marković, D. Secondary Metabolites from Gorgonian Corals of the Genus Eunicella: Structural Characterizations, Biological Activities, and Synthetic Approaches. Molecules 2020, 25, 129. https://doi.org/10.3390/molecules25010129

AMA Style

Matulja D, Kolympadi Markovic M, Ambrožić G, Laclef S, Pavelić SK, Marković D. Secondary Metabolites from Gorgonian Corals of the Genus Eunicella: Structural Characterizations, Biological Activities, and Synthetic Approaches. Molecules. 2020; 25(1):129. https://doi.org/10.3390/molecules25010129

Chicago/Turabian Style

Matulja, Dario, Maria Kolympadi Markovic, Gabriela Ambrožić, Sylvain Laclef, Sandra K. Pavelić, and Dean Marković. 2020. "Secondary Metabolites from Gorgonian Corals of the Genus Eunicella: Structural Characterizations, Biological Activities, and Synthetic Approaches" Molecules 25, no. 1: 129. https://doi.org/10.3390/molecules25010129

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