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Keywords = Eunicella genus

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26 pages, 3741 KiB  
Review
Secondary Metabolites from Gorgonian Corals of the Genus Eunicella: Structural Characterizations, Biological Activities, and Synthetic Approaches
by Dario Matulja, Maria Kolympadi Markovic, Gabriela Ambrožić, Sylvain Laclef, Sandra Kraljević Pavelić and Dean Marković
Molecules 2020, 25(1), 129; https://doi.org/10.3390/molecules25010129 - 28 Dec 2019
Cited by 11 | Viewed by 5589
Abstract
Gorgonian corals, which belong to the genus Eunicella, are known as natural sources of diverse compounds with unique structural characteristics and interesting bioactivities both in vitro and in vivo. This review is focused primarily on the secondary metabolites isolated from various Eunicella [...] Read more.
Gorgonian corals, which belong to the genus Eunicella, are known as natural sources of diverse compounds with unique structural characteristics and interesting bioactivities both in vitro and in vivo. This review is focused primarily on the secondary metabolites isolated from various Eunicella species. The chemical structures of 64 compounds were divided into three main groups and comprehensively presented: a) terpenoids, b) sterols, and c) alkaloids and nucleosides. The observed biological activities of depicted metabolites with an impact on cytotoxic, anti-inflammatory, and antimicrobial activities were reviewed. The most promising biological activities of certain metabolites point to potential candidates for further development in pharmaceutical, cosmetic, and other industries, and are highlighted. Total synthesis or the synthetic approaches towards the desired skeletons or natural products are also summarized. Full article
(This article belongs to the Special Issue Translational Approach to Antitumor Drugs)
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