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Open AccessArticle

Optical Resolution of Rimantadine

Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan
Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018 San Sebastián, Spain
IKERBASQUE, Basque Foundation for Science, María Díaz de Haro 3, Plaza Bizkaia, 48013 Bilbao, Spain
Authors to whom correspondence should be addressed.
Molecules 2019, 24(9), 1828;
Received: 20 April 2019 / Revised: 6 May 2019 / Accepted: 11 May 2019 / Published: 12 May 2019
(This article belongs to the Section Bioorganic Chemistry)
This work discloses a new procedure for the resolution of commercially available racemic rimantadine hydrochloride to enantiomerically pure (S)-rimantadine using (R)-phenoxypropionic acid as a recyclable resolving reagent. Good chemical yields, operational ease, and low-cost structure underscore the preparative value of this method for the production of enantiomerically pure rimantadine for medicinal or synthetic studies. View Full-Text
Keywords: optical resolution; rimantadine; enantiomers; practicality; chiral acids and amines optical resolution; rimantadine; enantiomers; practicality; chiral acids and amines
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MDPI and ACS Style

Han, J.; Takeda, R.; Sato, T.; Moriwaki, H.; Abe, H.; Izawa, K.; Soloshonok, V.A. Optical Resolution of Rimantadine. Molecules 2019, 24, 1828.

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