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Open AccessArticle

Optical Resolution of Rimantadine

1
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
2
Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan
3
Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018 San Sebastián, Spain
4
IKERBASQUE, Basque Foundation for Science, María Díaz de Haro 3, Plaza Bizkaia, 48013 Bilbao, Spain
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(9), 1828; https://doi.org/10.3390/molecules24091828
Received: 20 April 2019 / Revised: 6 May 2019 / Accepted: 11 May 2019 / Published: 12 May 2019
(This article belongs to the Section Bioorganic Chemistry)
This work discloses a new procedure for the resolution of commercially available racemic rimantadine hydrochloride to enantiomerically pure (S)-rimantadine using (R)-phenoxypropionic acid as a recyclable resolving reagent. Good chemical yields, operational ease, and low-cost structure underscore the preparative value of this method for the production of enantiomerically pure rimantadine for medicinal or synthetic studies. View Full-Text
Keywords: optical resolution; rimantadine; enantiomers; practicality; chiral acids and amines optical resolution; rimantadine; enantiomers; practicality; chiral acids and amines
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MDPI and ACS Style

Han, J.; Takeda, R.; Sato, T.; Moriwaki, H.; Abe, H.; Izawa, K.; Soloshonok, V.A. Optical Resolution of Rimantadine. Molecules 2019, 24, 1828.

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