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Rhinoclactones A-E, Resorcylic Acid Analogs from Desert Plant Endophytic Fungus Rhinocladiella similis

1
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
2
Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
3
Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this paper.
Academic Editor: Josphat Matasyoh
Molecules 2019, 24(7), 1405; https://doi.org/10.3390/molecules24071405
Received: 12 March 2019 / Revised: 5 April 2019 / Accepted: 8 April 2019 / Published: 10 April 2019
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Abstract

Seven resorcylic acid lactones (RALs) including five new analog rhinoclactones, A–E (1, 2, 46), were isolated from an endophytic fungus Rhinocladiella similis in the plant Agriophyllum squarrosum collected from the Tengger Desert of the Ningxia Province, China. The structures of these new compounds were determined by HR-ESI-MS (High Resolution Electrospray Ionization Mass Spectrometry), NMR data, modified Mosher’s method, and X-ray diffraction experiments. All compounds isolated from this fungus possessed the 16-OMe/14-OH, not the common 16-OH/14-OH or 16-OH/14-OMe groups on the aromatic ring, which are rarely found in nature. Compound 7 displayed cytotoxic activities against HCT116 and HeLa cancer cell lines. The possible biosynthesis of 17 is suggested, and the potential ecological roles of these fungal secondary metabolites is discussed. View Full-Text
Keywords: desert plant; Agriophyllum squarrosum; endophytic fungus; Rhinocladiella similis; rhinoclactones; cytotoxic activities desert plant; Agriophyllum squarrosum; endophytic fungus; Rhinocladiella similis; rhinoclactones; cytotoxic activities
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Li, L.; Zhang, X.; Tan, X.; Sun, B.; Wu, B.; Yu, M.; Zhang, T.; Zhang, Y.; Ding, G. Rhinoclactones A-E, Resorcylic Acid Analogs from Desert Plant Endophytic Fungus Rhinocladiella similis. Molecules 2019, 24, 1405.

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