Halogen-Substituted Triazolethioacetamides as a Potent Skeleton for the Development of Metallo-β-Lactamase Inhibitors
Abstract
:1. Introduction
2. Results and Discussion
3. Materials and Methods
3.1. General Information
3.2. Synthesis and Characterization
3.3 Determination of IC50 and Ki values
3.4. Docking Calculations
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Sample Availability: All the target compounds halogen-substituted triazolethioacetamides are available from the authors, the synthetic raw materials are purchased from the reagent company and the metallo-beta-lactamase used in the manuscript were provided from Professor Ke-wu Yang. |
Compds | ImiS | NDM-1 | VIM-2 |
---|---|---|---|
1 | 0.032 ± 0.004 | 0.96 ± 0.07 | - 1 |
2 | 0.045 ± 0.002 | 0.17 ± 0.02 | - |
3 | 0.051 ± 0.006 | 0.37 ± 0.05 | - |
4 | 0.27 ± 0.02 | - | - |
5 | 0.16 ± 0.03 | - | - |
6 | 0.78 ± 0.08 | - | - |
7 | 0.20 ± 0.04 | - | - |
8 | 0.26 ± 0.03 | - | - |
9 | 0.072 ± 0.005 | - | - |
10 | 0.98 ± 0.04 | - | - |
11 | >50 | - | - |
12 | 15.64 ± 3 | - | 38.9 ± 5 |
13 | 0.23 ± 0.09 | - | 2.8 ± 0.3 |
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Zhang, Y.; Yan, Y.; Liang, L.; Feng, J.; Wang, X.; Li, L.; Yang, K. Halogen-Substituted Triazolethioacetamides as a Potent Skeleton for the Development of Metallo-β-Lactamase Inhibitors. Molecules 2019, 24, 1174. https://doi.org/10.3390/molecules24061174
Zhang Y, Yan Y, Liang L, Feng J, Wang X, Li L, Yang K. Halogen-Substituted Triazolethioacetamides as a Potent Skeleton for the Development of Metallo-β-Lactamase Inhibitors. Molecules. 2019; 24(6):1174. https://doi.org/10.3390/molecules24061174
Chicago/Turabian StyleZhang, Yilin, Yong Yan, Lufan Liang, Jie Feng, Xuejun Wang, Li Li, and Kewu Yang. 2019. "Halogen-Substituted Triazolethioacetamides as a Potent Skeleton for the Development of Metallo-β-Lactamase Inhibitors" Molecules 24, no. 6: 1174. https://doi.org/10.3390/molecules24061174