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Molecules 2019, 24(3), 630; https://doi.org/10.3390/molecules24030630

Stereoselective Multicomponent Reactions in the Synthesis or Transformations of Epoxides and Aziridines

1
Centre of Excellence for Research in Sustainable Chemistry, Department of Chemistry, Federal University of São Carlos, 13565-905 São Carlos, SP, Brazil
2
São Carlos Institute of Chemistry, University of São Paulo, 13563-120 São Carlos, SP, Brazil
Dedicated to Professor Madalena Pinto on the occasion of her 70th anniversary.
*
Author to whom correspondence should be addressed.
Academic Editors: Maria Elizabeth Tiritan, Madalena Pinto and Carla Sofia Garcia Fernandes
Received: 16 January 2019 / Revised: 4 February 2019 / Accepted: 7 February 2019 / Published: 11 February 2019
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Abstract

Small ring heterocycles, such as epoxides and aziridines, are present in several natural products and are also highly versatile building blocks, frequently involved in the synthesis of numerous bioactive products and pharmaceuticals. Because of the potential for increased efficiency and selectivity, along with the advantages of environmentally benign synthetic procedures, multicomponent reactions (MCRs) have been explored in the synthesis and ring opening of these heterocyclic units. In this review, the recent advances in MCRs involving the synthesis and applications of epoxides and aziridines to the preparation of other heterocycles are discussed emphasizing the stereoselectivity of the reactions. View Full-Text
Keywords: multicomponent reactions; epoxides; aziridine; asymmetric synthesis; green synthesis multicomponent reactions; epoxides; aziridine; asymmetric synthesis; green synthesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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da Silva, A.R.; dos Santos, D.A.; Paixão, M.W.; Corrêa, A.G. Stereoselective Multicomponent Reactions in the Synthesis or Transformations of Epoxides and Aziridines. Molecules 2019, 24, 630.

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