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Molecules 2019, 24(3), 595; https://doi.org/10.3390/molecules24030595

Synthesis of Aromatic Rings Embedded in Polycyclic Scaffolds by Triyne Cycloaddition: Competition between Carbonylative and Non-Carbonylative Pathways

Laboratoire d’Innovation Thérapeutique, Université de Strasbourg, CNRS, 67000 Strasbourg, France
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Received: 21 January 2019 / Revised: 1 February 2019 / Accepted: 4 February 2019 / Published: 7 February 2019
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Abstract

Cycloadditions have emerged as some of the most useful reactions for the formation of polycyclic compounds. The carbonylative cycloaddition of triynes can lead to carbonylative and non-carbonylative competitive pathways, each leading to the formation of an aromatic ring. We report herein the one-pot synthesis of fully- and unsymmetrically-substituted tetracyclic 6,5,7,5-troponic and 6,5,6,5-benzenoid scaffolds using pre-organized triynes showing the competition between these two pathways. View Full-Text
Keywords: cyclotrimerization; carbonylative cycloaddition; tropone; benzenoid; polycycles; rhodium catalysis; one-pot reaction cyclotrimerization; carbonylative cycloaddition; tropone; benzenoid; polycycles; rhodium catalysis; one-pot reaction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Salacz, L.; Girard, N.; Suffert, J.; Blond, G. Synthesis of Aromatic Rings Embedded in Polycyclic Scaffolds by Triyne Cycloaddition: Competition between Carbonylative and Non-Carbonylative Pathways. Molecules 2019, 24, 595.

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