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Open AccessFeature PaperArticle

Synthesis of Aromatic Rings Embedded in Polycyclic Scaffolds by Triyne Cycloaddition: Competition between Carbonylative and Non-Carbonylative Pathways

Laboratoire d’Innovation Thérapeutique, Université de Strasbourg, CNRS, 67000 Strasbourg, France
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Molecules 2019, 24(3), 595; https://doi.org/10.3390/molecules24030595
Received: 21 January 2019 / Revised: 1 February 2019 / Accepted: 4 February 2019 / Published: 7 February 2019
Cycloadditions have emerged as some of the most useful reactions for the formation of polycyclic compounds. The carbonylative cycloaddition of triynes can lead to carbonylative and non-carbonylative competitive pathways, each leading to the formation of an aromatic ring. We report herein the one-pot synthesis of fully- and unsymmetrically-substituted tetracyclic 6,5,7,5-troponic and 6,5,6,5-benzenoid scaffolds using pre-organized triynes showing the competition between these two pathways. View Full-Text
Keywords: cyclotrimerization; carbonylative cycloaddition; tropone; benzenoid; polycycles; rhodium catalysis; one-pot reaction cyclotrimerization; carbonylative cycloaddition; tropone; benzenoid; polycycles; rhodium catalysis; one-pot reaction
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MDPI and ACS Style

Salacz, L.; Girard, N.; Suffert, J.; Blond, G. Synthesis of Aromatic Rings Embedded in Polycyclic Scaffolds by Triyne Cycloaddition: Competition between Carbonylative and Non-Carbonylative Pathways. Molecules 2019, 24, 595.

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