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Open AccessArticle

Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System

1
Department of Locomotive Rehabilitation Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan
2
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan
3
Department of Neurology, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki 372-0006, Japan
4
Department of Neurology International Medical Center, Saitama Medical University, Saitama 350-1298, Japan
5
Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Aichi 480-1195, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Botond Penke
Molecules 2019, 24(24), 4601; https://doi.org/10.3390/molecules24244601
Received: 19 November 2019 / Revised: 12 December 2019 / Accepted: 13 December 2019 / Published: 16 December 2019
(This article belongs to the Special Issue Amyloids in Neurodegenerative Diseases)
Human prion diseases are neurodegenerative disorders caused by prion protein. Although infectivity was historically detected only in the central nervous system and lymphoreticular tissues of patients with sporadic Creutzfeldt-Jakob disease, recent reports suggest that the seeding activity of Creutzfeldt-Jakob disease prions accumulates in various non-neuronal organs including the liver, kidney, and skin. Therefore, we reanalyzed autopsy samples collected from patients with sporadic and genetic human prion diseases and found that seeding activity exists in almost all digestive organs. Unexpectedly, activity in the esophagus reached a level of prion seeding activity close to that in the central nervous system in some CJD patients, indicating that the safety of endoscopic examinations should be reconsidered. View Full-Text
Keywords: prion; rt-quic prion; rt-quic
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Satoh, K.; Fuse, T.; Nonaka, T.; Dong, T.; Takao, M.; Nakagaki, T.; Ishibashi, D.; Taguchi, Y.; Mihara, B.; Iwasaki, Y.; Yoshida, M.; Nishida, N. Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System. Molecules 2019, 24, 4601.

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