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Open AccessArticle

Continuous Flow Photochemical and Thermal Multi-Step Synthesis of Bioactive 3-Arylmethylene-2,3-Dihydro-1H-Isoindolin-1-Ones

1
College of Science and Engineering, James Cook University, Townsville, QLD 4811, Australia
2
Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 S4-bis, 9000 Gent, Belgium
*
Author to whom correspondence should be addressed.
Academic Editor: Yasuharu Yoshimi
Molecules 2019, 24(24), 4527; https://doi.org/10.3390/molecules24244527
Received: 17 November 2019 / Revised: 4 December 2019 / Accepted: 10 December 2019 / Published: 11 December 2019
(This article belongs to the Special Issue New Insights in Photoredox Catalysis)
An effective multi-step continuous flow approach towards N-diaminoalkylated 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones, including the local anesthetic compound AL-12, has been realized. Compared to the traditional decoupled batch processes, the combined photochemical–thermal–thermal flow setup rapidly provides the desired target compounds in superior yields and significantly shorter reaction times. View Full-Text
Keywords: photochemistry; photodecarboxylation; phthalimide; continuous-flow photochemistry; multi-step synthesis; arylmethylene isoindolinones photochemistry; photodecarboxylation; phthalimide; continuous-flow photochemistry; multi-step synthesis; arylmethylene isoindolinones
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Mumtaz, S.; Robertson, M.J.; Oelgemöller, M. Continuous Flow Photochemical and Thermal Multi-Step Synthesis of Bioactive 3-Arylmethylene-2,3-Dihydro-1H-Isoindolin-1-Ones. Molecules 2019, 24, 4527.

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