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Open AccessArticle

Evodiamine Eliminates Colon Cancer Stem Cells via Suppressing Notch and Wnt Signaling

1
College of Pharmacy, Sookmyung Women’s University, Cheongparo-47 Gil, Yongsan Gu, Seoul 04312, Korea
2
Inland Aquaculture Research Center, National Institute of Fisheries Science, Changwon 51688, Korea
3
Research Institute of Pharmaceutical Sciences, Sookmyung Women’s University, Cheongparo-47 Gil, Yongsan Gu, Seoul 04312, Korea
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(24), 4520; https://doi.org/10.3390/molecules24244520
Received: 2 November 2019 / Revised: 9 December 2019 / Accepted: 9 December 2019 / Published: 10 December 2019
(This article belongs to the Section Natural Products Chemistry)
Evodiamine, an alkaloid contained in traditional Asian herbal medicines that have been used for hundreds years, is interesting due to its cytotoxic effects against many cancers. We examined the effect of evodiamine on the cancer stem cell (CSC) population and the bulk cultured cancer cells (BCC) of colon cancers to examine the double targeting effect. We found that three colon cancer cell lines’ BCC and CSC are effectively targeted by evodiamine. Evodiamine was able to suppress BCC proliferation and induce apoptosis of the cells captured in G2/M phase, as previously reported. However, evodiamine did not cause the accumulation of CSCs at a certain stage of the cell cycle, resulting in the elimination of stemness through an unknown mechanism. By analyzing the expression of 84 genes related to CSCs in two colon cancer cell lines’ CSC, as well as performing further informatics analyses, and quantitative RT-PCR analyses of 24 CSC genes, we found that evodiamine suppressed the expression of the genes that control key signaling pathways of CSC, namely, WNT and NOTCH signaling, to lead CSC elimination. These results suggest that evodiamine should be further developed for targeting both BCCs and CSCs in colon cancers. View Full-Text
Keywords: evodiamine; colorectal cancer; cancer stem cell; notch; WNT evodiamine; colorectal cancer; cancer stem cell; notch; WNT
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Kim, H.; Yu, Y.; Choi, S.; Lee, H.; Yu, J.; Lee, J.-H.; Kim, W.-Y. Evodiamine Eliminates Colon Cancer Stem Cells via Suppressing Notch and Wnt Signaling. Molecules 2019, 24, 4520.

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