Next Article in Journal
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease
Previous Article in Journal
What Is in Store for EPS Microalgae in the Next Decade?
Previous Article in Special Issue
Effect of Varying Concentrations of Docosahexaenoic Acid on Amyloid Beta (1–42) Aggregation: An Atomic Force Microscopy Study
 
Search for Articles:
Title / Keyword
Author / Affiliation
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
Journals
Molecules
Volume 24
Issue 23
10.3390/molecules24234297
molecules-logo
Submit to this Journal Review for this Journal Edit a Special Issue
► Article Menu

Article Menu

share announcement thumb_up
...
textsms
...
Article

Anti-Amyloidogenic Effects of Asarone Derivatives From Perilla frutescens Leaves Against Beta-Amyloid Aggregation and Nitric Oxide Production

by
Jae Eun Lee
1,†,‡,
Nayeon Kim
1,†,
Ji Yun Yeo
1,
Dae-Gun Seo
1,
Sunggun Kim
1,
Jae-Sun Lee
1,
Kwang Woo Hwang
2 and
So-Young Park
1,*
1
College of Pharmacy, Dankook University, 119 Dandae-ro, Dongnam-gu, Cheonan-si, Chungnam 31116, Korea
2
College of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
Present address: National Agrobiodiversity Center, Rural Development Administration, Jeonbuk 54874, Korea.
Academic Editor: Peter Koulen
Molecules 2019, 24(23), 4297; https://doi.org/10.3390/molecules24234297
Received: 14 October 2019 / Revised: 19 November 2019 / Accepted: 21 November 2019 / Published: 25 November 2019
(This article belongs to the Collection Neuroprotection Mediated by Natural Products and Their Chemical Derivatives)
View Full-Text Download PDF
Browse Figures

Abstract

Alzheimer’s disease (AD) is a progressive, neurodegenerative brain disorder associated with loss of memory and cognitive function. Beta-amyloid (Aβ) aggregates, in particular, are known to be highly neurotoxic and lead to neurodegeneration. Therefore, blockade or reduction of Aβ aggregation is a promising therapeutic approach in AD. We have previously reported an inhibitory effect of the methanol extract of Perilla frutescens (L.) Britton (Lamiaceae) and its hexane fraction on Aβ aggregation. Here, the hexane fraction of P. frutescens was subjected to diverse column chromatography based on activity-guided isolation methodology. This approach identified five asarone derivatives including 2,3-dimethoxy-5-(1E)-1-propen-1-yl-phenol (1), β-asarone (2), 3-(2,4,5-trimethoxyphenyl)-(2E)-2-propen-1-ol (3), asaronealdehyde (4), and α-asarone (5). All five asarone derivatives efficiently reduced the aggregation of Aβ and disaggregated preformed Aβ aggregates in a dose-dependent manner as determined by a Thioflavin T (ThT) fluorescence assay. Furthermore, asarone derivatives protected PC12 cells from Aβ aggregate-induced toxicity by reducing the aggregation of Aβ, and significantly reduced NO production from LPS-stimulated BV2 microglial cells. Taken together, these results suggest that asarone derivatives derived from P. frutescens are neuroprotective and have the prophylactic and therapeutic potential in AD. View Full-Text
Keywords: Perilla frutescens; asarone derivative; Alzheimer’s disease; beta-amyloid aggregation; beta-amyloid disaggregation; nitric oxide Perilla frutescens; asarone derivative; Alzheimer’s disease; beta-amyloid aggregation; beta-amyloid disaggregation; nitric oxide
►▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Supplementary Material

SciFeed

Share and Cite

MDPI and ACS Style

Lee, J.E.; Kim, N.; Yeo, J.Y.; Seo, D.-G.; Kim, S.; Lee, J.-S.; Hwang, K.W.; Park, S.-Y. Anti-Amyloidogenic Effects of Asarone Derivatives From Perilla frutescens Leaves Against Beta-Amyloid Aggregation and Nitric Oxide Production. Molecules 2019, 24, 4297. https://doi.org/10.3390/molecules24234297

AMA Style

Lee JE, Kim N, Yeo JY, Seo D-G, Kim S, Lee J-S, Hwang KW, Park S-Y. Anti-Amyloidogenic Effects of Asarone Derivatives From Perilla frutescens Leaves Against Beta-Amyloid Aggregation and Nitric Oxide Production. Molecules. 2019; 24(23):4297. https://doi.org/10.3390/molecules24234297

Chicago/Turabian Style

Lee, Jae E.; Kim, Nayeon; Yeo, Ji Y.; Seo, Dae-Gun; Kim, Sunggun; Lee, Jae-Sun; Hwang, Kwang W.; Park, So-Young. 2019. "Anti-Amyloidogenic Effects of Asarone Derivatives From Perilla frutescens Leaves Against Beta-Amyloid Aggregation and Nitric Oxide Production" Molecules 24, no. 23: 4297. https://doi.org/10.3390/molecules24234297

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop