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Review

Structure and Function of Multimeric G-Quadruplexes

1
The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, 166 10 Prague, Czech Republic
2
Department of Biochemistry and Microbiology, University of Chemistry and Technology, 166 28 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(17), 3074; https://doi.org/10.3390/molecules24173074
Received: 13 August 2019 / Revised: 21 August 2019 / Accepted: 22 August 2019 / Published: 24 August 2019
G-quadruplexes are noncanonical nucleic acid structures formed from stacked guanine tetrads. They are frequently used as building blocks and functional elements in fields such as synthetic biology and also thought to play widespread biological roles. G-quadruplexes are often studied as monomers, but can also form a variety of higher-order structures. This increases the structural and functional diversity of G-quadruplexes, and recent evidence suggests that it could also be biologically important. In this review, we describe the types of multimeric topologies adopted by G-quadruplexes and highlight what is known about their sequence requirements. We also summarize the limited information available about potential biological roles of multimeric G-quadruplexes and suggest new approaches that could facilitate future studies of these structures. View Full-Text
Keywords: G-quadruplex; dimer; tetramer; multimer; oligomer; telomere; promoter; R-loop; DNA:RNA hybrid G-quadruplex; dimer; tetramer; multimer; oligomer; telomere; promoter; R-loop; DNA:RNA hybrid
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MDPI and ACS Style

Kolesnikova, S.; Curtis, E.A. Structure and Function of Multimeric G-Quadruplexes. Molecules 2019, 24, 3074. https://doi.org/10.3390/molecules24173074

AMA Style

Kolesnikova S, Curtis EA. Structure and Function of Multimeric G-Quadruplexes. Molecules. 2019; 24(17):3074. https://doi.org/10.3390/molecules24173074

Chicago/Turabian Style

Kolesnikova, Sofia; Curtis, Edward A. 2019. "Structure and Function of Multimeric G-Quadruplexes" Molecules 24, no. 17: 3074. https://doi.org/10.3390/molecules24173074

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