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Open AccessArticle

Terpene Glycosides from Sanguisorba officinalis and Their Anti-Inflammatory Effects

The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
School of Nursing, Sichuan Tianyi College, Mianzhu 618200, China
Syngenta Jealott’s Hill International Research Centre, Berkshire RG42 6EY, UK
Authors to whom correspondence should be addressed.
Molecules 2019, 24(16), 2906;
Received: 16 July 2019 / Revised: 6 August 2019 / Accepted: 8 August 2019 / Published: 10 August 2019
(This article belongs to the Section Natural Products Chemistry)
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Two new terpene glycosides (12) along with two known analogs (34) were obtained from the root of Sanguisorba officinalis, which is a common traditional Chinese medicine (TCM). Their structures were elucidated by nuclear magnetic resonance (NMR), electrospray ionization high resolution mass spectrometry (HRESIMS), and a hydrolysis reaction, as well as comparison of these data with the literature data. Compounds 14 exhibited anti-inflammatory properties in vitro by attenuating the production of inflammatory mediators, such as nitric oxide (NO) as well as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). An anti-inflammatory assay based on the zebrafish experimental platform indicated that compound 1 had good anti-inflammatory activity in vivo by not only regulating the distribution, but also by reducing the amount of the macrophages of the zebrafish exposed to copper sulfate. View Full-Text
Keywords: terpene glycosides; structural elucidation; Sanguisorba officinalis; zebrafish; anti-inflammatory terpene glycosides; structural elucidation; Sanguisorba officinalis; zebrafish; anti-inflammatory

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Guo, D.-L.; Chen, J.-F.; Tan, L.; Jin, M.-Y.; Ju, F.; Cao, Z.-X.; Deng, F.; Wang, L.-N.; Gu, Y.-C.; Deng, Y. Terpene Glycosides from Sanguisorba officinalis and Their Anti-Inflammatory Effects. Molecules 2019, 24, 2906.

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