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Hydrogen Sulfide: Recent Progression and Perspectives for the Treatment of Diabetic Nephropathy

1
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
2
School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, China
3
National University of Singapore (Suzhou) Research Institute, Suzhou 215000, China
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(15), 2857; https://doi.org/10.3390/molecules24152857
Received: 24 June 2019 / Revised: 29 July 2019 / Accepted: 5 August 2019 / Published: 6 August 2019
(This article belongs to the Special Issue Sulfur Compounds and Human Health)
Diabetic kidney disease develops in approximately 40% of diabetic patients and is a major cause of chronic kidney diseases (CKD) and end stage kidney disease (ESKD) worldwide. Hydrogen sulfide (H2S), the third gasotransmitter after nitric oxide (NO) and carbon monoxide (CO), is synthesized in nearly all organs, including the kidney. Though studies on H2S regulation of renal physiology and pathophysiology are still in its infancy, emerging evidence shows that H2S production by renal cells is reduced under disease states and H2S donors ameliorate kidney injury. Specifically, aberrant H2S level is implicated in various renal pathological conditions including diabetic nephropathy. This review presents the roles of H2S in diabetic renal disease and the underlying mechanisms for the protective effects of H2S against diabetic renal damage. H2S may serve as fundamental strategies to treat diabetic kidney disease. These H2S treatment modalities include precursors for H2S synthesis, H2S donors, and natural plant-derived compounds. Despite accumulating evidence from experimental studies suggests the potential role of the H2S signaling pathway in the treatment of diabetic nephropathy, these results need further clinical translation. Expanding understanding of H2S in the kidney may be vital to translate H2S to be a novel therapy for diabetic renal disease. View Full-Text
Keywords: hydrogen sulfide; renal physiology; oxidative stress; renin-angiotensin system; diabetic nephropathy hydrogen sulfide; renal physiology; oxidative stress; renin-angiotensin system; diabetic nephropathy
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MDPI and ACS Style

Sun, H.-J.; Wu, Z.-Y.; Cao, L.; Zhu, M.-Y.; Liu, T.-T.; Guo, L.; Lin, Y.; Nie, X.-W.; Bian, J.-S. Hydrogen Sulfide: Recent Progression and Perspectives for the Treatment of Diabetic Nephropathy. Molecules 2019, 24, 2857.

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