Next Article in Journal
Estimating the Solubility, Solution Thermodynamics, and Molecular Interaction of Aliskiren Hemifumarate in Alkylimidazolium Based Ionic Liquids
Previous Article in Journal
Mammalian DNA Polymerase Kappa Activity and Specificity
 
 
Review

Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological

1
Laboratório de Imunoparasitologia, Departamento de Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil
2
Programa de Pós-graduação em Bioquímica, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil
3
Programa de Pós-graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil
4
Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1800-166 Lisbon, Portugal
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(15), 2806; https://doi.org/10.3390/molecules24152806
Received: 13 July 2019 / Revised: 29 July 2019 / Accepted: 30 July 2019 / Published: 1 August 2019
Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in vitro models as potential new antimicrobials. Thus, the purpose of this review is to present the possibilities of using dithiocarbamate compounds as potential new antitrypanosomatids-drugs, which could be used for the pharmacological control of Chagas disease, leishmaniasis, and African trypanosomiasis. View Full-Text
Keywords: dithiocarbamates; DETC; antiparasitic activity; Trypanosomatids; Chagas disease; leishmaniasis; African trypanosomiasis dithiocarbamates; DETC; antiparasitic activity; Trypanosomatids; Chagas disease; leishmaniasis; African trypanosomiasis
Show Figures

Graphical abstract

MDPI and ACS Style

Oliveira, J.W.d.F.; Rocha, H.A.O.; de Medeiros, W.M.T.Q.; Silva, M.S. Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological. Molecules 2019, 24, 2806. https://doi.org/10.3390/molecules24152806

AMA Style

Oliveira JWdF, Rocha HAO, de Medeiros WMTQ, Silva MS. Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological. Molecules. 2019; 24(15):2806. https://doi.org/10.3390/molecules24152806

Chicago/Turabian Style

Oliveira, Johny Wysllas de Freitas, Hugo Alexandre Oliveira Rocha, Wendy Marina Toscano Queiroz de Medeiros, and Marcelo Sousa Silva. 2019. "Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological" Molecules 24, no. 15: 2806. https://doi.org/10.3390/molecules24152806

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop