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Treatment with, Resveratrol, a SIRT1 Activator, Prevents Zearalenone-Induced Lactic Acid Metabolism Disorder in Rat Sertoli Cells

1,2,3, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2,3, 1,2,3,* and 1,2,3,*
1
College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu, China
2
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, Jiangsu, China
3
Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu, China
*
Authors to whom correspondence should be addressed.
Molecules 2019, 24(13), 2474; https://doi.org/10.3390/molecules24132474
Received: 17 June 2019 / Revised: 4 July 2019 / Accepted: 4 July 2019 / Published: 5 July 2019
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Abstract

Zearalenone (ZEA) interferes with the function of the male reproductive system, but its molecular mechanism has yet to be completely elucidated. Sertoli cells (SCs) are important in the male reproductive system. Silencing information regulator 1 (SIRT1) is a cell metabolism sensor and resveratrol (RSV) is an activator of SIRT1. In this study we investigated whether SIRT1 is involved in the regulation of ZEA-induced lactate metabolism disorder in SCs. The results showed that the cytotoxicity of ZEA toward SCs increased with increasing ZEA concentration. Moreover, ZEA induced a decrease in the production of lactic acid and pyruvate of SCs and inhibited the expression of glycolytic genes and lactic acid production-related proteins. ZEA also led to a decreased expression of SIRT1 in energy receptors and decreased ATP levels in SCs. However, the ZEA-induced cytotoxicity and decline in lactic acid production in SCs were alleviated by the use of RSV, which is an activator of SIRT1. In summary, ZEA decreased lactic acid production in SCs, while the treatment with an SIRT1 activator, RSV, restored the inhibition of lactic acid production in SCs and reduced cytotoxicity of ZEA toward SCs. View Full-Text
Keywords: Sertoli cells; zearalenone; lactic acid; SIRT1; resveratrol Sertoli cells; zearalenone; lactic acid; SIRT1; resveratrol
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Cai, P.; Feng, N.; Zheng, W.; Zheng, H.; Zou, H.; Yuan, Y.; Liu, X.; Liu, Z.; Gu, J.; Bian, J. Treatment with, Resveratrol, a SIRT1 Activator, Prevents Zearalenone-Induced Lactic Acid Metabolism Disorder in Rat Sertoli Cells. Molecules 2019, 24, 2474.

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