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Open AccessArticle

Rapid and Efficient Separation of Decursin and Decursinol Angelate from Angelica gigas Nakai using Ionic Liquid, (BMIm)BF4, Combined with Crystallization

1
College of Pharmacy, CHA University, Sungnam 13844, Korea
2
College of Pharmacy, Korea University, Sejong City 30019, Korea
3
College of Pharmacy, Dongguk University Seoul, Goyang-si, Gyeonggi-do 10326, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Maria Lisa Clodoveo and Filomena Corbo
Molecules 2019, 24(13), 2390; https://doi.org/10.3390/molecules24132390
Received: 29 May 2019 / Revised: 25 June 2019 / Accepted: 26 June 2019 / Published: 28 June 2019
(This article belongs to the Special Issue Green Extraction of Natural Products)
Ionic liquids (ILs) have gained much attention as alternative solvents to volatile organic solvents due to their attractive properties. This study aimed to develop an efficient method for the selective separation of decursin (D) and decursinol angelate (DA) from Angelica gigas Nakai (A. gigas) using ILs and crystallization. The IL 1-butyl-3-methylimidazolium tetrafluoroborate ((BMIm)BF4) was the most efficient at extracting D and DA. Parameters including solid-to-liquid ratio, time, and temperature were optimized by response surface methodology (RSM). Under optimal extraction conditions (1 g/6.5 mL solid-to-liquid ratio, 60 °C temperature, and 120 min time), the extraction yields of D and DA were 43.32 mg/g (97.06%) and 17.87 mg/g (97.12%), respectively. Moreover, drowning out crystallization using deionized water (DW) as an anti-solvent offered an excellent ability to recover D and DA from the A. gigas–(BMIm)BF4 extraction solution. The rates of recovery and the total purity of D and DA were found to be greater than 97%. Therefore, a rapid and efficient method of combining ILs with crystallization was effectively achieved for the selective separation of D and DA. This approach is assumed to be beneficial in the pharmaceutical industry for the effective obtention of D- and DA-enriched products. View Full-Text
Keywords: ionic liquids; decursin; decursinol angelate; Angelica gigas Nakai; crystallization ionic liquids; decursin; decursinol angelate; Angelica gigas Nakai; crystallization
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MDPI and ACS Style

Kiyonga, A.N.; An, J.-H.; Lee, K.Y.; Lim, C.; Suh, Y.-G.; Chin, Y.-W.; Jung, K. Rapid and Efficient Separation of Decursin and Decursinol Angelate from Angelica gigas Nakai using Ionic Liquid, (BMIm)BF4, Combined with Crystallization. Molecules 2019, 24, 2390.

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