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Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi

1
Institute of Biology, Gansu Academy of Sciences, Lanzhou 730000, Gansu, China
2
Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, Gansu, China
3
Key Laboratory of Microbial Resources Exploition and Application of Gansu Province, Institute of Biology, Gansu Academy of Sciences, Lanzhou 730000, Gansu, China
*
Author to whom correspondence should be addressed.
Molecules 2019, 24(12), 2231; https://doi.org/10.3390/molecules24122231
Received: 5 May 2019 / Revised: 3 June 2019 / Accepted: 6 June 2019 / Published: 14 June 2019
Cordycepin (3′-deoxyadenosine), a cytotoxic nucleoside analogue found in Cordyceps militaris, has attracted much attention due to its therapeutic potential and biological value. Cordycepin interacts with multiple medicinal targets associated with cancer, tumor, inflammation, oxidant, polyadenylation of mRNA, etc. The investigation of the medicinal drug actions supports the discovery of novel targets and the development of new drugs to enhance the therapeutic potency and reduce toxicity. Cordycepin may be of great value owing to its medicinal potential as an external drug, such as in cosmeceutical, traumatic, antalgic and muscle strain applications. In addition, the biological application of cordycepin, for example, as a ligand, has been used to uncover molecular structures. Notably, studies that investigated the metabolic mechanisms of cordycepin-producing fungi have yielded significant information related to the biosynthesis of high levels of cordycepin. Here, we summarized the medicinal targets, biological applications, cytotoxicity, delivery carriers, stability, and pros/cons of cordycepin in clinical applications, as well as described the metabolic mechanisms of cordycepin in cordycepin-producing fungi. We posit that new approaches, including single-cell analysis, have the potential to enhance medicinal potency and unravel all facets of metabolic mechanisms of cordycepin in Cordyceps militaris. View Full-Text
Keywords: cordycepin; medicinal targets; biological value; metabolic mechanisms cordycepin; medicinal targets; biological value; metabolic mechanisms
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Qin, P.; Li, X.; Yang, H.; Wang, Z.-Y.; Lu, D. Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi. Molecules 2019, 24, 2231.

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