Next Article in Journal
Modeling the Solvent Extraction of Cadmium(II) from Aqueous Chloride Solutions by 2-pyridyl Ketoximes: A Coordination Chemistry Approach
Previous Article in Journal
Continuous Monitoring of Shelf Lives of Materials by Application of Data Loggers with Implemented Kinetic Parameters
Open AccessArticle

Recyclable and Stable α-Methylproline-Derived Chiral Ligands for the Chemical Dynamic Kinetic Resolution of free C,N-Unprotected α-Amino Acids

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Derek J. McPhee
Molecules 2019, 24(12), 2218; https://doi.org/10.3390/molecules24122218
Received: 28 May 2019 / Revised: 6 June 2019 / Accepted: 6 June 2019 / Published: 13 June 2019
(This article belongs to the Section Inorganic Chemistry)
A novel special designed, stable, and recyclable chiral ligand bearing a quaternary carbon was developed for chemical dynamic kinetic resolution (DKR) of free C,N-unprotected racemic α-amino acids via Schiff base intermediates. This method furnishes high yields with excellent enantioselectivity, has a broad substrate scope, and uses operationally simple and convenient conditions. The present chemical DKR is a practical and useful method for the preparation of enantiopure α-amino acids. View Full-Text
Keywords: quaternary carbon; dynamic kinetic resolution; unprotected α-amino acids; Schiff base intermediates; ligands quaternary carbon; dynamic kinetic resolution; unprotected α-amino acids; Schiff base intermediates; ligands
Show Figures

Figure 1

MDPI and ACS Style

Shu, S.; Zhao, L.; Zhou, S.; Wu, C.; Liu, H.; Wang, J. Recyclable and Stable α-Methylproline-Derived Chiral Ligands for the Chemical Dynamic Kinetic Resolution of free C,N-Unprotected α-Amino Acids. Molecules 2019, 24, 2218.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop