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Porous Silicon-Based Aptasensors: The Next Generation of Label-Free Devices for Health Monitoring

1
Institute for Microelectronics and Microsystems, Via P. Castellino 111, 80131 Naples, Italy
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Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
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Department of Chemical Sciences, University of Naples Federico II, Via Cynthia, 80126 Naples, Italy
4
Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2019, 24(12), 2216; https://doi.org/10.3390/molecules24122216
Received: 29 April 2019 / Revised: 4 June 2019 / Accepted: 12 June 2019 / Published: 13 June 2019
(This article belongs to the Special Issue Molecules for Biotechnologies)
Aptamers are artificial nucleic acid ligands identified and obtained from combinatorial libraries of synthetic nucleic acids through the in vitro process SELEX (systematic evolution of ligands by exponential enrichment). Aptamers are able to bind an ample range of non-nucleic acid targets with great specificity and affinity. Devices based on aptamers as bio-recognition elements open up a new generation of biosensors called aptasensors. This review focuses on some recent achievements in the design of advanced label-free optical aptasensors using porous silicon (PSi) as a transducer surface for the detection of pathogenic microorganisms and diagnostic molecules with high sensitivity, reliability and low limit of detection (LoD). View Full-Text
Keywords: aptasensor; porous silicon; surface modification; aptamer; optical label free-sensing aptasensor; porous silicon; surface modification; aptamer; optical label free-sensing
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Terracciano, M.; Rea, I.; Borbone, N.; Moretta, R.; Oliviero, G.; Piccialli, G.; De Stefano, L. Porous Silicon-Based Aptasensors: The Next Generation of Label-Free Devices for Health Monitoring. Molecules 2019, 24, 2216.

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