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Putative Roles of Plant-Derived Tannins in Neurodegenerative and Neuropsychiatry Disorders: An Updated Review

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Neurochemicalbiology and Genetics Laboratory (NGL), Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan
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Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China
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Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan
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Institute of Home and Food Sciences, Government College University, Faisalabad 38000, Pakistan
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Faculty of Engineering and Natural Sciences, Department of Molecular Biology and Genetics, Uskudar University, Istanbul 34662, Turkey
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Authors to whom correspondence should be addressed.
Academic Editor: Paula B. Andrade
Molecules 2019, 24(12), 2213; https://doi.org/10.3390/molecules24122213
Received: 4 April 2019 / Revised: 7 May 2019 / Accepted: 8 May 2019 / Published: 13 June 2019
Neurodegenerative and neuropsychiatric diseases are characterized by the structural and functional abnormalities of neurons in certain regions of the brain. These abnormalities, which can result in progressive neuronal degeneration and functional disability, are incurable to date. Although comprehensive efforts have been made to figure out effective therapies against these diseases, partial success has been achieved and complete functional recovery is still not a reality. At present, plants and plant-derived compounds are getting more attention because of a plethora of pharmacological properties, and they are proving to be a better and safer target as therapeutic interventions. This review aims to highlight the roles of tannins, ‘the polyphenol phytochemicals’, in tackling neurodegenerative diseases including Alzheimer’s and Parkinson’s diseases as well as neuropsychiatric disorders like depression. Among the multifarious pharmacological properties of tannins, anti-oxidative, anti-inflammatory, and anti-cholinesterase activities are emphasized more in terms of neuroprotection. The current review also throws light on mechanistic pathways by which various classes of tannins execute neuroprotective effects. Despite their beneficial properties, some harmful effects of tannins have also been elaborated. View Full-Text
Keywords: neurodegenerative diseases (NDDs); neuropsychiatric diseases; Alzheimer’s disease (AD); Parkinson’s disease (PD); depression neurodegenerative diseases (NDDs); neuropsychiatric diseases; Alzheimer’s disease (AD); Parkinson’s disease (PD); depression
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Hussain, G.; Huang, J.; Rasul, A.; Anwar, H.; Imran, A.; Maqbool, J.; Razzaq, A.; Aziz, N.; Makhdoom, E.H.; Konuk, M.; Sun, T. Putative Roles of Plant-Derived Tannins in Neurodegenerative and Neuropsychiatry Disorders: An Updated Review. Molecules 2019, 24, 2213.

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