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Molecules 2019, 24(1), 204; https://doi.org/10.3390/molecules24010204

Biological Activities and Chemical Composition of Santolina africana Jord. et Fourr. Aerial Part Essential Oil from Algeria: Occurrence of Polyacetylene Derivatives

1
Laboratoire des Produits Naturels, Département de Biologie, Université Abou Bekr Belkaïd, Imama Tlemcen 13000, Algeria
2
Université de Corse-CNRS, UMR 6134 SPE, Route des Sanguinaires, 20000 Ajaccio, France
3
Laboratoire d’Ecologie et Gestion des Ecosystèmes Naturels, Département d’Ecologie et Environnement, Université Abou Bekr Belkaïd, Imama Tlemcen 13000, Algeria
*
Author to whom correspondence should be addressed.
Academic Editor: Francesca Mancianti
Received: 24 November 2018 / Revised: 28 December 2018 / Accepted: 29 December 2018 / Published: 8 January 2019
(This article belongs to the Special Issue Biological Activities of Essential Oils)
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Abstract

The chemical composition of 18 oil samples of Santolina africana isolated from aerial parts at full flowering, collected in three locations in eastern Algeria was determined by GC(RI), GC/MS and 13C-NMR analysis. The major components were: germacrene D, myrcene, spathulenol, α-bisabolol, β-pinene, 1,8-cineole, cis-chrysanthenol, capillene, santolina alcohol, camphor, terpinen-4-ol and lyratol. The chemical composition appeared homogeneous and characterized by the occurrence of four derivatives which exhibited a conjugated alkene dialkyne moiety. They were identified for the first time in an essential oil from S. africana. The collective oil sample exhibited moderate antimicrobial and antioxidant activities whereas the anti-inflammatory activity presented a real potential. IC50 value of Santolina africana essential oil (0.065 ± 0.004 mg/mL) is 5-fold higher than IC50 value of NDGA used as positive control. View Full-Text
Keywords: Santolina africana Jord. et Fourr.; Asteraceae; essential oil composition; 13C-NMR; antimicrobial activity; antioxidant activity; anti-inflammatory activity Santolina africana Jord. et Fourr.; Asteraceae; essential oil composition; 13C-NMR; antimicrobial activity; antioxidant activity; anti-inflammatory activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Malti, C.E.W.; Baccati, C.; Mariani, M.; Hassani, F.; Babali, B.; Atik-Bekkara, F.; Paoli, M.; Maury, J.; Tomi, F.; Bekhechi, C. Biological Activities and Chemical Composition of Santolina africana Jord. et Fourr. Aerial Part Essential Oil from Algeria: Occurrence of Polyacetylene Derivatives. Molecules 2019, 24, 204.

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