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Molecules 2018, 23(9), 2361;

Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert

Departamento de Química y Farmacia, Facultad de Ciencias, Universidad Católica del Norte, Angamos 0610, Antofagasta 1240000, Chile
Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Casilla 567, Valdivia 5090000, Chile
Center for Interdisciplinary Studies on the Nervous System (CISNe), Universidad Austral de Chile, Valdivia 5090000, Chile
Laboratorio de Productos Naturales, Departamento de Química, Facultad de Ciencias Básicas, Universidad de Antofagasta, Casilla 170, Antofagasta 1240000, Chile
Departamento de Ciencias Químicas, Universidad Andres Bello, Campus Viña del Mar, Quillota 980, Viña del Mar 2520000, Chile
Departamento de Química, Facultad de Ciencias, Universidad de Chile, Santiago 8320198, Chile
Authors to whom correspondence should be addressed.
Received: 7 August 2018 / Revised: 7 September 2018 / Accepted: 14 September 2018 / Published: 15 September 2018
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Forty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. quadrangularis by means of hyphenated UHPLC-quadrupole Orbitrap mass spectrometry, and seven isolated compounds were tested regarding gastroprotective activity using the HCl/EtOH-induced lesion model in mice. A new tremetone (compound 6) is reported based on spectroscopic evidence. The isolated clerodanes and tremetones showed gastroprotective activity in a mouse model, evidenced by compound 7 (p-coumaroyloxytremetone), which showed the highest gastroprotective activity (76%), which was higher than the control drug lansoprazole (72%). Our findings revealed that several constituents of this plant have gastroprotective activity, and particularly, p-coumaroyloxytremetone could be considered as a lead molecule to explore new gastroprotective agents. This plant is a rich source of biologically active tremetones and terpenoids which can support the ethnobotanical use of the plant. View Full-Text
Keywords: clerodanes; tremetones; gastroprotective; LC-MS/MS; gastric ulcer; endemic plants clerodanes; tremetones; gastroprotective; LC-MS/MS; gastric ulcer; endemic plants

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ardiles, A.; Barrientos, R.; Simirgiotis, M.J.; Bórquez, J.; Sepúlveda, B.; Areche, C. Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert. Molecules 2018, 23, 2361.

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