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Molecules 2018, 23(9), 2194; https://doi.org/10.3390/molecules23092194

o-Carboranylalkoxy-1,3,5-Triazine Derivatives: Synthesis, Characterization, X-ray Structural Studies, and Biological Activity

1
School of Pharmacy, Jiangsu University, Zhenjiang 212013, Jiangsu, China
2
Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea
3
Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan
4
Department of Chemistry, College of Natural Sciences, Chosun University, 309 Pilmundaero, Dong-gu, Gwangju 61452, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Piotr Kaszyński
Received: 27 July 2018 / Revised: 23 August 2018 / Accepted: 29 August 2018 / Published: 30 August 2018
(This article belongs to the Special Issue Advances in Materials Derived from Polyhedral Boron Clusters)
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Abstract

Morpholine- and bis(2-methoxyethyl)amine-substituted 1,3,5-triazine derivatives containing an alkoxy-o-carborane in the 6-position of the triazine ring were successfully synthesized. The molecular structures of the methoxy- and ethoxy-o-carboranyl-1,3,5-triazines were established by X-ray crystallography. In vitro studies showed that the methylene bridged morpholine- and bis(2-methoxyethyl)amine-substituted o-carboranyl-1,3,5-triazines accumulated to high levels in B16 melanoma cells and exhibited higher cytotoxicity than p-boronophenylalanine. View Full-Text
Keywords: o-Carborane; heterocyclic system; 1,3,5-triazine; morpholine; boron neutron capture therapy o-Carborane; heterocyclic system; 1,3,5-triazine; morpholine; boron neutron capture therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jin, G.F.; Ban, H.S.; Nakamura, H.; Lee, J.-D. o-Carboranylalkoxy-1,3,5-Triazine Derivatives: Synthesis, Characterization, X-ray Structural Studies, and Biological Activity. Molecules 2018, 23, 2194.

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