Next Article in Journal
Targeting Breast Cancer Stem Cells to Overcome Treatment Resistance
Next Article in Special Issue
Synthesis and Ceramic Conversion of a New Organodecaborane Preceramic Polymer with High-Ceramic-Yield
Previous Article in Journal
The Targeted Pesticides as Acetylcholinesterase Inhibitors: Comprehensive Cross-Organism Molecular Modelling Studies Performed to Anticipate the Pharmacology of Harmfulness to Humans In Vitro
Previous Article in Special Issue
Ferrocene and Transition Metal Bis(Dicarbollides) as Platform for Design of Rotatory Molecular Switches
Article

o-Carboranylalkoxy-1,3,5-Triazine Derivatives: Synthesis, Characterization, X-ray Structural Studies, and Biological Activity

1
School of Pharmacy, Jiangsu University, Zhenjiang 212013, Jiangsu, China
2
Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea
3
Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan
4
Department of Chemistry, College of Natural Sciences, Chosun University, 309 Pilmundaero, Dong-gu, Gwangju 61452, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Piotr Kaszyński
Molecules 2018, 23(9), 2194; https://doi.org/10.3390/molecules23092194
Received: 27 July 2018 / Revised: 23 August 2018 / Accepted: 29 August 2018 / Published: 30 August 2018
(This article belongs to the Special Issue Advances in Materials Derived from Polyhedral Boron Clusters)
Morpholine- and bis(2-methoxyethyl)amine-substituted 1,3,5-triazine derivatives containing an alkoxy-o-carborane in the 6-position of the triazine ring were successfully synthesized. The molecular structures of the methoxy- and ethoxy-o-carboranyl-1,3,5-triazines were established by X-ray crystallography. In vitro studies showed that the methylene bridged morpholine- and bis(2-methoxyethyl)amine-substituted o-carboranyl-1,3,5-triazines accumulated to high levels in B16 melanoma cells and exhibited higher cytotoxicity than p-boronophenylalanine. View Full-Text
Keywords: o-Carborane; heterocyclic system; 1,3,5-triazine; morpholine; boron neutron capture therapy o-Carborane; heterocyclic system; 1,3,5-triazine; morpholine; boron neutron capture therapy
Show Figures

Graphical abstract

MDPI and ACS Style

Jin, G.F.; Ban, H.S.; Nakamura, H.; Lee, J.-D. o-Carboranylalkoxy-1,3,5-Triazine Derivatives: Synthesis, Characterization, X-ray Structural Studies, and Biological Activity. Molecules 2018, 23, 2194. https://doi.org/10.3390/molecules23092194

AMA Style

Jin GF, Ban HS, Nakamura H, Lee J-D. o-Carboranylalkoxy-1,3,5-Triazine Derivatives: Synthesis, Characterization, X-ray Structural Studies, and Biological Activity. Molecules. 2018; 23(9):2194. https://doi.org/10.3390/molecules23092194

Chicago/Turabian Style

Jin, Guo F., Hyun S. Ban, Hiroyuki Nakamura, and Jong-Dae Lee. 2018. "o-Carboranylalkoxy-1,3,5-Triazine Derivatives: Synthesis, Characterization, X-ray Structural Studies, and Biological Activity" Molecules 23, no. 9: 2194. https://doi.org/10.3390/molecules23092194

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop