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Molecules 2018, 23(8), 1997; https://doi.org/10.3390/molecules23081997

Chemical Synthesis of Rare, Deoxy-Amino Sugars Containing Bacterial Glycoconjugates as Potential Vaccine Candidates

Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India
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Received: 10 July 2018 / Revised: 4 August 2018 / Accepted: 8 August 2018 / Published: 10 August 2018
(This article belongs to the Special Issue Conjugate Vaccines from Carbohydrate Antigens)

Abstract

Bacteria often contain rare deoxy amino sugars which are absent in the host cells. This structural difference can be harnessed for the development of vaccines. Over the last fifteen years, remarkable progress has been made toward the development of novel and efficient protocols for obtaining the rare sugar building blocks and their stereoselective assembly to construct conjugation ready bacterial glycans. In this review, we discuss the total synthesis of a variety of rare sugar containing bacterial glycoconjugates which are potential vaccine candidates. View Full-Text
Keywords: bacterial glycoconjugates; rare deoxy-amino sugars; total synthesis; vaccine candidates; zwitterionic polysaccharides; stereoselective glycosylation bacterial glycoconjugates; rare deoxy-amino sugars; total synthesis; vaccine candidates; zwitterionic polysaccharides; stereoselective glycosylation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Behera, A.; Kulkarni, S.S. Chemical Synthesis of Rare, Deoxy-Amino Sugars Containing Bacterial Glycoconjugates as Potential Vaccine Candidates. Molecules 2018, 23, 1997.

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