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Molecules 2018, 23(7), 1757; https://doi.org/10.3390/molecules23071757

Low-Molecular-Weight Heparins: Reduced Size Particulate Systems for Improved Therapeutic Outcomes

1
School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China
2
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China
*
Author to whom correspondence should be addressed.
Academic Editors: Marco Guerrini and Edwin Alexander Yates
Received: 24 May 2018 / Revised: 21 June 2018 / Accepted: 4 July 2018 / Published: 18 July 2018
(This article belongs to the Special Issue Heparan Sulfate and Heparin: Challenges and Controversies)
Full-Text   |   PDF [665 KB, uploaded 18 July 2018]   |  

Abstract

A wide range of diseases have been treated using low-molecular-weight heparins (LMWHs), the drug of choice for anticoagulation. Owing to their better pharmacokinetic features compared to those of unfractionated heparin (uFH), several systems incorporating LMWHs have been investigated to deliver and improve their therapeutic outcomes, especially through development of their micro- and nano-particles. This review article describes current perspectives on the fabrication, characterization, and application of LMWHs-loaded micro- and nano-particles to achieve ameliorated bioavailability. The valuable applications of LMWH will continue to encourage researchers to identify efficient delivery systems that have specific release characteristics and ameliorated bioavailability, overcoming the challenges presented by biological obstructions and the physicochemical properties of LMWHs. View Full-Text
Keywords: low molecular weight heparins; stability; encapsulation; polymers; bioavailability low molecular weight heparins; stability; encapsulation; polymers; bioavailability
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Akhtar, F.; Wan, X.; Wu, G.; Kesse, S.; Wang, S.; He, S. Low-Molecular-Weight Heparins: Reduced Size Particulate Systems for Improved Therapeutic Outcomes. Molecules 2018, 23, 1757.

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