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Recent Advances in the Synthesis of Glycoconjugates for Vaccine Development
Open AccessReview

Anomeric O-Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs

Department of Chemistry, University of California, Davis, CA 95616, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Paul Kovac, Peng Xu and Helene Pfister
Molecules 2018, 23(7), 1742;
Received: 25 June 2018 / Revised: 12 July 2018 / Accepted: 13 July 2018 / Published: 17 July 2018
(This article belongs to the Special Issue Conjugate Vaccines from Carbohydrate Antigens)
Carbohydrates mediate a wide range of biological interactions, and understanding these processes benefits the development of new therapeutics. Isolating sufficient quantities of glycoconjugates from biological samples remains a significant challenge. With advances in chemical and enzymatic carbohydrate synthesis, the availability of complex carbohydrates is increasing and developing methods for stereoselective conjugation these polar head groups to proteins and lipids is critically important for pharmaceutical applications. The aim of this review is to provide an overview of commonly employed strategies for installing a functionalized linker at the anomeric position as well as examples of further transformations that have successfully led to glycoconjugation to vaccine constructs for biological evaluation as carbohydrate-based therapeutics. View Full-Text
Keywords: carbohydrates; glycosylation; glycosides; glycoconjugates; anomeric functionalization carbohydrates; glycosylation; glycosides; glycoconjugates; anomeric functionalization
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MDPI and ACS Style

Park, S.S.; Hsieh, H.-W.; Gervay-Hague, J. Anomeric O-Functionalization of Carbohydrates for Chemical Conjugation to Vaccine Constructs. Molecules 2018, 23, 1742.

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